产品名称

英文名称：Barasertib (AZD1152-HQPA)

同义词

722544-51-6、AZD1152-HQPA、barasertib-hQPA、AZD-1152HQPA、Barasertib (AZD1152-HQPA)、defosbarasertib、2-(3-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide、UNII-29P8LWS24N、AZD-1152-HQPA、INH 34、INH-34

产品性质

CAS编号：722544-51-6

分子式：C26H30FN7O3

分子量：507.56

MDL号：MFCD10687152

PubChem编号：16007391

英文别名：722544-51-6|AZD1152-HQPA|barasertib-hQPA|AZD-1152HQPA|Barasertib (AZD1152-HQPA)|defosbarasertib|2-(3-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide|UNII-29P8LWS24N|AZD-1152-HQPA|INH 34|INH-34

规格或纯度：≥97%

英文名称：Barasertib (AZD1152-HQPA)

生化机理：AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines. .Potent, selective Aurora B kinase inhibitor (IC 50 = 0.37 nM). Induces apoptosis in vitro . Antitumor agent. Cell-permeable. Active in vitro and in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AZD1152-HQPA是AZD-1152的活性代谢物，AZD1152-HQPA (Barasertib)是Aurora B 高选择性抑制剂，IC50为0.37 nM，比对Aurora A的抑制性高100倍。A highly selective ARK-2 inhibitorAZD1152-HQPA is the active metabolite of AZD-1152, AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold more selective for Aurora B over Aurora A.A highly selective ARK-2 inhibitor

IUPAC Name：2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide

INCHI：InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)

InChi Key：QYZOGCMHVIGURT-UHFFFAOYSA-N

Canonical SMILES：CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

Isomeric SMILES：CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

WGK Germany：3

PubChem CID：16007391

CAS Registry No.：722544-51-6

DiscoveRx TREEspot：AZD-1152HQPA|

ChEMBL Ligand：CHEMBL215152

RCSB PDB Ligand：YJA

溶解性：DMSO ≥100mg/mL Water ≥100mg/mL Ethanol ≥2.8mg/mL

折光率：1.68

沸点：796.7° C at 760 mmHg

产品包装