产品名称

英文名称：Myriocin

同义词

Myriocin、thermozymocidin、35891-70-4、ISP-1、ISP-I、Myriocin from Mycelia sterilia、(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid、CHEBI582124、YRM4E8R9ST、(E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic a

产品性质

CAS编号：35891-70-4

分子式：C21H39NO6

分子量：401.54

MDL号：MFCD01632772

PubChem编号：6438394

英文别名：Myriocin|thermozymocidin|35891-70-4|ISP-1|ISP-I|Myriocin from Mycelia sterilia|(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid|CHEBI582124|YRM4E8R9ST|(E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic a

规格或纯度：98%

英文名称：Myriocin

生化机理：Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been sμggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.Highly potent serine palmitoyltransferase inhibitor (K i = 0.28 nM). Shows 10 times the immunosuppressant potency of cyclosporine . Depletes cellular sphingolipids and induces apoptosis. Inhibits proliferation (IC 50 = 15 nM, CTLL-1

应用：An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.

IUPAC Name：(E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid

INCHI：InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1

InChi Key：ZZIKIHCNFWXKDY-GNTQXERDSA-N

Canonical SMILES：CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O

Isomeric SMILES：CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O

WGK Germany：3

RTECS：JX3890000

PubChem CID：6438394

UN Number：2811

ChEMBL Ligand：CHEMBL55076

Wikipedia：Myriocin

CAS Registry No.：35891-70-4

RCSB PDB Ligand：VRP

溶解性：Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water.

密度：1.123

敏感性：对光线和湿度敏感

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装