产品名称

英文名称：Dynasore

同义词

Dynasore、304448-55-3、Dynamin Inhibitor I, Dynasore、CHEMBL1209885、N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide、N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide、N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxy、3-羟基萘-2-羧酸(3,4-二羟基苯亚甲基)酰肼、N'-(3,4-二羟基苯亚甲基)-3-羟基-2-萘甲酰肼、动力抑制剂I

产品性质

CAS编号：304448-55-3

分子式：C18H14N2O4

分子量：322.31

MDL号：MFCD00292551

PubChem编号：135533054

别名：3-羟基萘-2-羧酸(3,4-二羟基苯亚甲基)酰肼|N'-(3,4-二羟基苯亚甲基)-3-羟基-2-萘甲酰肼|动力抑制剂I

英文别名：Dynasore|304448-55-3|Dynamin Inhibitor I, Dynasore|CHEMBL1209885|N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide|N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide|N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxy

规格或纯度：≥98%

英文名称：Dynasore

生化机理：Dynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II. Members of the Dynamin family, including Dynamin I, Dynamin II and Dynamin III, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by blocking coated vesicle formation. Dynamin Inhibitor I, Dynasore is an inhibitor of DRP1.Cell-permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.

应用：An inhibitor of Dynamin I and Dynamin II

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Dynasore是一种可渗透细胞的，可逆的，非竞争性的dynamin（发动蛋白）抑制剂，抑制dynamin 1/2的GTPase活性，IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。An inhibitor of Dynamin I and Dynamin IIDynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPaseAn inhibitor of Dynamin I and Dynamin II

IUPAC Name：N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide

INCHI：InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChi Key：SYNDQCRDGGCQRZ-VXLYETTFSA-N

Canonical SMILES：C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O

Isomeric SMILES：C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O

PubChem CID：135533054

溶解性：Soluble in DMSO (100 mM), and ethanol (5 mM). Insoluble in water

敏感性：对热敏感；对光敏感

产品包装