产品名称

英文名称：CYC116

同义词

693228-63-6、CYC-116、CYC116、4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine、CYC 116、CHEMBL482967、Kinome_636、4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine、YAX4981K2D、4-methyl-5-(2-((4-morpholinophenyl)amino

产品性质

CAS编号：693228-63-6

分子式：C18H20N6OS

分子量：368.46

PubChem编号：6420138

英文别名：693228-63-6|CYC-116|CYC116|4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine|CYC 116|CHEMBL482967|Kinome_636|4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine|YAX4981K2D|4-methyl-5-(2-((4-morpholinophenyl)amino

规格或纯度：98%

英文名称：CYC116

生化机理：CYC-116 is an orally bioavailable，small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Product DescriptionCYC116 is apotent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.

ALogP：2.6

IUPAC Name：4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

INCHI：InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)

InChi Key：GPSZYOIFQZPWEJ-UHFFFAOYSA-N

Canonical SMILES：CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

Isomeric SMILES：CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

PubChem CID：6420138

溶解性：DMSO 24 mg/mL heatWater <1 mg/mL Ethanol <1 mg/mL

产品包装