产品名称

英文名称：BIX 02188

同义词

BIX02188、1094614-84-2、334949-59-6、BIX-02188、BIX 02188、(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide、(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

产品性质

CAS编号：1094614-84-2

分子式：C25H24N4O2

分子量：412.48

PubChem编号：135398492

英文别名：BIX02188|1094614-84-2|334949-59-6|BIX-02188|BIX 02188|(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide|(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide|

规格或纯度：≥98%

英文名称：BIX 02188

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：BIX 02188是一种选择性的MEK5抑制剂，IC50为4.3 nM，也抑制ERK5催化活性，IC50为810 nM，且不抑制与其密切相关的激酶MEK1， MEK2， ERK2，和JNK2BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

IUPAC Name：3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indole-6-carboxamide

INCHI：InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)

InChi Key：WGPXKFOFEXJMBD-UHFFFAOYSA-N

Canonical SMILES：CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O

Isomeric SMILES：CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O

PubChem CID：135398492

CAS Registry No.：1094614-84-2

溶解性：DMSO 43 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

产品包装