产品名称

英文名称：Ruxolitinib (INCB018424)

同义词

Ruxolitinib、941678-49-5、INCB018424、Ruxolitinib (INCB018424)、(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile、INCB 018424、R-Ruxolitinib、INCB-018424、INC424、UNII-82S8X8XX8H、82S8X8XX8H、CHEBI66919、(R)-ruxolitinib、INCB184、INCB 018424、INCB018424、INCB-018424、鲁索替尼、鲁索利替尼、卢索替尼、芦可替尼

产品性质

CAS编号：941678-49-5

分子式：C17H18N6

分子量：306.37

PubChem编号：25126798

别名：INCB 018424|INCB018424|INCB-018424|鲁索替尼|鲁索利替尼|卢索替尼|芦可替尼

英文别名：Ruxolitinib|941678-49-5|INCB018424|Ruxolitinib (INCB018424)|(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile|INCB 018424|R-Ruxolitinib|INCB-018424|INC424|UNII-82S8X8XX8H|82S8X8XX8H|CHEBI66919|(R)-ruxolitinib|INCB184

规格或纯度：≥98%

英文名称：Ruxolitinib (INCB018424)

生化机理：Ruxolitinib (INCB018424) is a JAK inhibitor of JAK1 (IC50 = 2.7 nM), JAK2 (IC50 = 4.5 nM), and JAK3 (IC50 = 322 nM). JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth factor receptors and cytokines.Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC 50 values\xa0of 3.3,\xa02.8 and\xa0428 nM for JAK1, JAK2 and JAK3 respectively in vitro ). Inhibits IL-6 signaling (IC 50 = 281nM). Orally bioavailable.

应用：An inhibitor of JAK1, JAK2, and JAK3.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ruxolitinib (INCB018424)是第一个应用于临床的、有效的、选择性的JAK1/2抑制剂，IC50为3.3 nM/2.8 nM。作用于JAK1， JAK2与 作用于JAK3相比，选择性强130倍多。An inhibitor of JAK1, JAK2, and JAK3.INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.An inhibitor of JAK1, JAK2, and JAK3.

IUPAC Name：(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile

INCHI：InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

InChi Key：HFNKQEVNSGCOJV-OAHLLOKOSA-N

Canonical SMILES：C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Isomeric SMILES：C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

PubChem CID：25126798

溶解性：Soluble in DMSO (61 mg/ml at 25 °C), ethanol (15 mg/ml) with warming, DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and methanol.

产品包装