产品名称

英文名称：(S)-(+)-Ibuprofen

同义词

(S)-(+)-Ibuprofen、DEXIBUPROFEN、51146-56-6、(S)-Ibuprofen、(S)-2-(4-Isobutylphenyl)propanoic acid、S(+)-Ibuprofen、(S)-(+)-2-(4-Isobutylphenyl)propionic acid、Seractil、s-ibuprofen、d-Ibuproten、(+)-(S)-p-Isobutylhydratropic acid、(S)-(+)-4-Isobutyl-alpha-methylphe、(S)-(+)-2-(4-异丁苯基)丙酸

产品性质

CAS编号：51146-56-6

分子式：(CH3)2CHCH2C6H4CH(CH3)CO2H

分子量：206.28

Beilstein号：3590022

MDL号：MFCD00069289

PubChem编号：39912

别名：(S)-(+)-2-(4-异丁苯基)丙酸

英文别名：(S)-(+)-Ibuprofen|DEXIBUPROFEN|51146-56-6|(S)-Ibuprofen|(S)-2-(4-Isobutylphenyl)propanoic acid|S(+)-Ibuprofen|(S)-(+)-2-(4-Isobutylphenyl)propionic acid|Seractil|s-ibuprofen|d-Ibuproten|(+)-(S)-p-Isobutylhydratropic acid|(S)-(+)-4-Isobutyl-alpha-methylphe

规格或纯度：>98.0%(GC)

英文名称：(S)-(+)-Ibuprofen

生化机理：非选择性COX抑制剂（COX1和COX2的IC 50值分别为2.9和1.1μM）。非甾体抗炎药（NSAID）。快速越过血脑屏障。

应用：( S )-(+)-布洛芬可用作合成水凝胶的起始物料，具有通过酶介导水解释放的潜在能力。 用于药代动力学研究的抗炎药布洛芬的对映体。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：(S)-Ibuprofen is the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 μM and 7.2-8.2 μM, respectively). (S)-Ibuprofen acts as a non-steroidal analgesic and antiinflammatory agent. This compound’s inhibition of Cox-1 and Cox-2 and activation of PPARα and PPARγ isoforms may be responsible for its pharmacological effects.用于药代动力学研究的抗炎药布洛芬的对映体。(S)-Ibuprofen is the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 μM and 7.2-8.2 μM, respectively). (S)-Ibuprofen acts as a non-steroidal analgesic and antiinflammatory agent. This compound’s inhibition of Cox-1 and Cox-2 and activation of PPARα and PPARγ isoforms may be responsible for its pharmacological effects. (S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.Enantiomeric form of the anti-inflammatory agent ibuprofen used in pharmacokinetic studies.

ALogP：3.5

IUPAC Name：(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid

INCHI：InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

InChi Key：HEFNNWSXXWATRW-JTQLQIEISA-N

Canonical SMILES：CC(C)CC1=CC=C(C=C1)C(C)C(=O)O

Isomeric SMILES：C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O

WGK Germany：3

PubChem CID：39912

Reaxy-Rn：3590020

溶解性：Soluble in DMSO (100 mM), ethanol (100 mM), dichloromethane, ethyl acetate, and methanol. Insoluble in water.

比旋光度：59°

闪点(℉)：>235.4 °F

闪点(℃)：>113 °C

熔点：49-53°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品包装