产品名称

英文名称：Zaltidine

同义词

Zaltidine、85604-00-8、CP-57361、2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine、85604-00-8 (free base)、54HY424479、1-(4-(2-methyl-1H-imidazol-4-yl)thiazol-2-yl)guanidine、1-(4-(2-methyl-1H-imidazol-5-yl)thiazol-2-yl)guanidine、Zaltidinum、Zaltidina

产品性质

CAS编号：85604-00-8

分子式：C8H10N6S

分子量：222.27

PubChem编号：56051

英文别名：Zaltidine|85604-00-8|CP-57361|2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine|85604-00-8 (free base)|54HY424479|1-(4-(2-methyl-1H-imidazol-4-yl)thiazol-2-yl)guanidine|1-(4-(2-methyl-1H-imidazol-5-yl)thiazol-2-yl)guanidine|Zaltidinum|Zaltidina|

规格或纯度：≥98%

英文名称：Zaltidine

生化机理：DescriptionIC50 Value N/AZaltidine is a H2-receptor antagonist, which has the antisecretory action.in vitro N/Ain vivo In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85% and 97% inhibition of M.A.O. at peak (3 h post-dose) and 20% and 23% inhibition at 24 h, respectively; inhibition of basal acid output was 97% at 3 h and 50% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks' treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86% and 19%, respectively (p less than 0.001) [2].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Zaltidine(CP-57361)是H2受体拮抗剂，有抗分泌活性。

IUPAC Name：2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine

INCHI：InChI=1S/C8H10N6S/c1-4-11-2-5(12-4)6-3-15-8(13-6)14-7(9)10/h2-3H,1H3,(H,11,12)(H4,9,10,13,14)

InChi Key：GIMNAEMRNXUAQP-UHFFFAOYSA-N

Canonical SMILES：CC1=NC=C(N1)C2=CSC(=N2)N=C(N)N

Isomeric SMILES：CC1=NC=C(N1)C2=CSC(=N2)N=C(N)N

PubChem CID：56051

溶解性：DMSO

产品包装