产品名称

英文名称：Zosuquidar

同义词

Zosuquidar、167354-41-8、Zosuquidar [INN]、Zosuquidar Trihydrochloride、Ly335979、AB5K82X98Y、LY-335979、UNII-AB5K82X98Y、NCGC00274062-01、ZQU、ZOSUQUIDAR [MI]、ZOSUQUIDAR [WHO-DD]、CHEMBL444172、CHEMBL3907347、DTXSID9057894、SCHEMBL12432743、CHEBI94717、GTPL11788、IHOVFY

产品性质

CAS编号：167354-41-8

分子式：C32H31F2N3O2

分子量：527.6

PubChem编号：3036703

英文别名：Zosuquidar|167354-41-8|Zosuquidar [INN]|Zosuquidar Trihydrochloride|Ly335979|AB5K82X98Y|LY-335979|UNII-AB5K82X98Y|NCGC00274062-01|ZQU|ZOSUQUIDAR [MI]|ZOSUQUIDAR [WHO-DD]|CHEMBL444172|CHEMBL3907347|DTXSID9057894|SCHEMBL12432743|CHEBI94717|GTPL11788|IHOVFY

英文名称：Zosuquidar

生化机理：Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multidrμg resistance with Ki of 60 nM. Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrμg resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. Zosuquidar is a compound of antineoplastic drμg candidates currently under development.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(2R)-1-[4-[(2S,4R)-3,3-difluoro-11-tetracyclo[10.4.0.02,4.05,10]hexadeca-1(16),5,7,9,12,14-hexaenyl]piperazin-1-yl]-3-quinolin-5-yloxypropan-2-ol

INCHI：InChI=1S/C32H31F2N3O2/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27/h1-14,21,29-31,38H,15-20H2/t21-,29-,30+,31?/m1/s1

InChi Key：IHOVFYSQUDPMCN-XAKVHENESA-N

Canonical SMILES：C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47

Isomeric SMILES：C1CN(CCN1C[C@H](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[C@H]6[C@H](C6(F)F)C7=CC=CC=C47

PubChem CID：3036703

DrugBank Ligand：DB06191

BindingDB Ligand：50420186

CAS Registry No.：167354-41-8

ChEMBL Ligand：CHEMBL444172

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

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