产品名称

英文名称：3,3',5-Triiodo-L-thyronine

同义词

triiodothyronine 、 UNII-06LU7C9H1V 、 REGID_for_CID_5920 、 Thyrolar-0.25 、 Triiodothyronine, l- 、 06LU7C9H1V 、 DTXSID8023216 、 KBioSS_002577 、 Triiodothyronine (T3) 、 3,5,3'-Tri-iodo-L-thyronine 、 3,5,3'-Triiodo-L-thyronine 、 BCBcMAP01_000192 、 L-3-(4-(4-H、T3 碘噻罗宁 、 O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸

产品性质

CAS编号：6893-02-3

分子式：C15H12I3NO4

分子量：650.98

MDL号：MFCD00002593

PubChem编号：5920

别名：T3 碘噻罗宁 | O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸

英文别名：triiodothyronine | UNII-06LU7C9H1V | REGID_for_CID_5920 | Thyrolar-0.25 | Triiodothyronine, l- | 06LU7C9H1V | DTXSID8023216 | KBioSS_002577 | Triiodothyronine (T3) | 3,5,3'-Tri-iodo-L-thyronine | 3,5,3'-Triiodo-L-thyronine | BCBcMAP01_000192 | L-3-(4-(4-H

规格或纯度：>98.0%(HPLC)

英文名称：3,3',5-Triiodo-L-thyronine

生化机理：3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus

应用：3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Liothyronine 是一种有效的甲状腺激素。Liothyronine 是有效的 TRα 和 TRβ 激动剂，对 hTRα 和 hTRβ 的 Ki 值均为 2.33 nM。应用3,3′5-三碘-L-甲状腺原氨酸可用于胰岛素样生长因子I的检测，采用双抗体放射免疫分析法。该产品还可用于293T细胞的体外转染。

ALogP：1.7

PubChem SID：488179960

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179960

IUPAC Name：(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid

INCHI：InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChi Key：AUYYCJSJGJYCDS-LBPRGKRZSA-N

Canonical SMILES：C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

Isomeric SMILES：C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O

RTECS：AY6750000

PubChem CID：5920

Reaxy-Rn：2710227

DrugBank Ligand：DB00279

ChEBI：CHEBI18258

CAS Registry No.：6893-02-3

ChEMBL Ligand：CHEMBL1544

BindingDB Ligand：18860

Wikipedia：Liothyronine

NURSA Ligand：10.1621/1QGKELTJ7R

RCSB PDB Ligand：T3

PEP：t3

DrugCentral Ligand：1585

溶解性：3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

敏感性：对光线敏感

比旋光度：23° (C=5,1mol/L HClEtOH=12)

熔点：234-238°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：5510

产品包装