产品名称

英文名称：Vinblastine

同义词

HY-17418、Vinblastinum [INN-Latin]、VINCRISTINE SULFATE IMPURITY H [EP IMPURITY]、cid_5388983、methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),、长春花碱

产品性质

CAS编号：865-21-4

分子式：C46H58N4O9

分子量：810.97

PubChem编号：13342

别名：长春花碱

英文别名：HY-17418|Vinblastinum [INN-Latin]|VINCRISTINE SULFATE IMPURITY H [EP IMPURITY]|cid_5388983|methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),

规格或纯度：98%

英文名称：Vinblastine

生化机理：Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. This effect is concentration related (EC50, approximately 88 microM), reversible, and independent of phrenic nerve stimulation. The elevation in baseline tension is unaffected by nAChR blockade via d-tubocurarine, but is dependent upon the presence of extracellular calcium. In human Burkitt lymphoma CA46 cells, vinblastine (IC50 values, 1.0 nM). It binds tubulin, thereby inhibiting the assembly of microtubules.It is used to treat certain kinds of cancer, including Hodgkin

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Vinblastine抑制微管形成，抑制nAChR活性，IC50为8.9 μM。Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.

IUPAC Name：methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

INCHI：InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

InChi Key：JXLYSJRDGCGARV-CFWMRBGOSA-N

Canonical SMILES：CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

Isomeric SMILES：CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

PubChem CID：13342

DrugBank Ligand：DB00570

CAS Registry No.：865-21-4

ChEMBL Ligand：CHEMBL159

Wikipedia：Vinblastine

ChEBI：CHEBI27375

RCSB PDB Ligand：VLB

PEP：vinblastine

DrugCentral Ligand：2823

溶解性：25°C DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL

产品包装