L-(+)-麦角硫因

产品分类

化学和生化试剂/高端化学/化学合成/还原剂

产品名称

中文名称：L-(+)-麦角硫因

英文名称：L-(+)-Ergothioneine

同义词

ERGOTHIONEINE、497-30-3、L-(+)-Ergothioneine、L-Ergothioneine、Sympectothion、Ergothionine、l-Thioneine、Thiolhistidine-betaine、Thioneine、(S)-3-(2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate、BDZ3DQM98W、Thiasine、(S)-(1-Carboxy-2-(2-mercapt、(S)-α-羧基-N,N,N-三甲基-2-巯基-1H-咪唑-4-乙酰胆碱 内盐、麦角硫碱

产品性质

CAS编号：497-30-3

分子式：C9H15N3O2S

分子量：229.3

EC号：207-843-5

MDL号：MFCD00167474

PubChem编号：5351619

规格或纯度：≥98%

英文名称：L-(+)-Ergothioneine

生化机理：L-(+)-麦角硫因(ET)在氧化应激组织中浓度最高，在血液、晶状体、骨髓、精液和肝脏中浓度最高。它是一种抗氧化剂，通过清除活性氧和活性氮，防止细胞凋亡。抗氧化活性主要来源于巯基。它是SLC22A4（溶质载体族22，成员4）转运体的底物。在肺泡巨噬细胞中，阻止肿瘤坏死因子(TNF)α释放白细胞介素-8 (IL-8)。IL-8是一种炎性细胞因子。它还能调节肝、肾的氧化损伤，并对脂质过氧化有保护作用。它还负责内源性谷胱甘肽和α-生育酚的保存。ET是一种抗氧化剂，可以抵御γ和紫外线辐射。在紫外线照射的人皮肤成纤维细胞中，它可以清除活性氧(ROS)，并抑制基质金属蛋白酶1 (MMP1)的表达。它还可能防止紫外线辐射引起的皮肤衰老。

应用：An antioxidant and free radical scavenger

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：L-(+)-麦角硫因适用于研究它与2,2′- 和4,4′-联吡啶二硫化物（2-Py-S-S-2-Py和4-Py-S-S-4-Py）的反应性。它也可用于实验细胞的孵育，同时进行ATM（Ataxia毛细血管扩张症突变）或ATR （ATM-和RAD3-相关）的体外激酶活性测定。L-(+)-麦角硫因已被用于1、作为卵丘-卵母细胞复合物(COC)成熟培养基的组成部分，检测其对脂质过氧化形成的保护作用；2、作为一种抗氧化化合物用于检测2型糖尿病患者；3、作为可溶性载体蛋白22A4 (SLC22A4)转运检测的阳性对照。Ergothioneine is a stable antioxidant that can be found under conditions of excessive oxidative stress in plant and animal tissue. Ergothioneine can scavenge free radicals and protect cells from UV-induced ROS with higher efficiency than antioxidants coenzyme Q(10) or idebenone. The compound could be a non-toxic thiol buffering antioxidant, enhance cell viability induced by hydrogen peroxide (H2O2), and inhibit DNA oxidation by peroxynitrite (ONOO-) in the human neuronal hybridoma cell line (N-18-RE-105).An antioxidant and free radical scavengerApplicationL - (+) - ergot sulfur is suitable for studying its reactivity with 2,2 '- and 4,4' - bipyridine disulfides (2-Py-S-S-2-Py and 4-Py-S-S-4-Py).It can also be used for the incubation of experimental cells and for in vitro kinase activity measurement of ATM (Ataxia telangiectasia mutation) or ATR (ATM - and RAD3- related).L - (+) - ergot has been used to1. As a component of the cumulus oocyte complex (COC) maturation medium, its protective effect on lipid peroxidation formation was tested;2. As an antioxidant compound, it is used to detect type 2 diabetes patients;3. As a positive control for soluble carrier protein 22A4 (SLC22A4) transport detection.

PubChem SID：488195377

IUPAC Name：(2S)-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-(trimethylazaniumyl)propanoate

INCHI：InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1

InChi Key：SSISHJJTAXXQAX-ZETCQYMHSA-N

Canonical SMILES：C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)[O-]

WGK Germany：3

PubChem CID：5351619

溶解性：Soluble in water (50 mg/ml), acetone, hot ethanol, and methanol.

熔点：255 - 259 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：Eyeshields, Gloves, type N95 (US)

产品包装