产品名称

英文名称：Aristolochic acid A

同义词

Aristolochic acid、Aristolochic acid A、313-67-7、Aristolochic acid I、Aristolochin、Tardolyt、Aristolochic acid-I、ARISTOLOCHINE、TR 1736、Aristolochiazaeure、NSC-50413、Aristolochic acid 1、8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid、CCRIS 1544、8-甲氧基-3,4-亚甲二氧基-10-硝基菲-1-甲酸

产品性质

CAS编号：313-67-7

分子式：C17H11NO7

分子量：341.27

EC号：206-238-3

MDL号：MFCD00004996

PubChem编号：2236

别名：8-甲氧基-3,4-亚甲二氧基-10-硝基菲-1-甲酸

英文别名：Aristolochic acid|Aristolochic acid A|313-67-7|Aristolochic acid I|Aristolochin|Tardolyt|Aristolochic acid-I|ARISTOLOCHINE|TR 1736|Aristolochiazaeure|NSC-50413|Aristolochic acid 1|8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid|CCRIS 1544

规格或纯度：>98%

英文名称：Aristolochic acid A

生化机理：强有力的磷脂酶A2抑制剂，包括钙离子载体诱导的中性粒细胞中磷脂酶A2的活性。在实验动物模型中肾脏肿瘤引发剂。

应用：马兜铃酸A是一种强效的磷脂酶A2抑制剂。马兜铃酸A诱导大鼠肾脏肿瘤的形成和人肾近端肾小管上皮细胞凋亡。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：马兜铃酸也被称为马兜铃总酸、增噬力酸或木通甲素，是一类具有致癌性和肾毒性的硝基菲羧酸。这类有机化合物天然存在于诸如马兜铃属及细辛属等马兜铃科植物中，而这些植物曾广泛地被用作中草药。此外，依靠吸食这类植物生存的蝴蝶体内也有马兜铃酸。马兜铃酸A是一种强效的磷脂酶A2抑制剂。马兜铃酸A诱导大鼠肾脏肿瘤的形成和人肾近端肾小管上皮细胞凋亡。Aristolochic Acid is an alkaloid that was originally derived from Aristolochia radix. This compound is a potent PLA2 enzyme inhibitor and also suppresses edema-inducing activity as well as direct and indirect hemolytic activity. Specifically, Aristolochic Acid displays anti-inflammatory activity against edema in mouse foot pads induced by PLA2. Other experiments have shown this agent to be associated with aristolochic acid nephropathy. Mechanistic studies have reported Aristolochic Acid to play a regulatory role towards genes in DNA repair processes and responses to DNA damage stimulus, regulation of cell cycle, and apoptosis. More detailed studies have shown this compound to up-regulate GADD 45β, NAIP genes and down-regulate TP53, PARP1, ERCC1, OGG1/2, MGMT, and ERCC2 genes. Furthermore, a down-regulation of gene expression in anti-oxidant enzymes was also observed by Aristolochic Acid treatment of human kidney tubular cells. These studies suggest that oxidative stress plays a role in the cytotoxicity of Aristolochic Acid.Aristolochic acid A is a potent phospholipase A2 inhibitor. Aristolochic acid A induces tumor formation in rat kidneys and apoptosis in human renal proximal tubular epithelial cells.

IUPAC Name：8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid

INCHI：InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

InChi Key：BBFQZRXNYIEMAW-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O

Isomeric SMILES：COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O

WGK Germany：3

RTECS：CF3325000

关联CAS：313-67-7

PubChem CID：2236

NSC Number：11926

MeSH Entry Terms：8-methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid;aristolochic acid;aristolochic acid A;aristolochic acid I;aristolochic acid I, sodium salt;sodium aristolochate;Tardolyt

溶解性：Soluble in ethanol, acetone, chloroform, ether, aniline, alkalies, acetic acid, and DMSO (25 mg/ml), slightly soluble in water.practically Insoluble in benzene, and carbon disulfide.

密度：1.571

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

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