产品名称

英文名称：Adenosine 3′,5′-cyclic monophosphate

同义词

Cyclic AMP、cAMP、60-92-4、Adenosine 3',5'-cyclic monophosphate、3',5'-cyclic AMP、Adenosine 3',5'-cyclophosphate、Adenosine 3',5'-phosphate、cyclic 3',5'-AMP、Adenosine cyclic monophosphate、Cyclic Adenosine Monophosphate、cyclic 3',5'-Adenylic acid、Adenosine 3',5、环化腺苷酸、cAMP、腺苷-3',5'-环单磷酸、腺苷环磷酸酯、腺苷-3',5'-单磷酸、3',5'-环AMP

产品性质

CAS编号：60-92-4

分子式：C10H12N5O6P

分子量：329.21

Beilstein号：52645

EC号：200-492-9

MDL号：MFCD00005845

PubChem编号：6076

别名：环化腺苷酸|cAMP|腺苷-3',5'-环单磷酸|腺苷环磷酸酯|腺苷-3',5'-单磷酸|3',5'-环AMP

英文别名：Cyclic AMP|cAMP|60-92-4|Adenosine 3',5'-cyclic monophosphate|3',5'-cyclic AMP|Adenosine 3',5'-cyclophosphate|Adenosine 3',5'-phosphate|cyclic 3',5'-AMP|Adenosine cyclic monophosphate|Cyclic Adenosine Monophosphate|cyclic 3',5'-Adenylic acid|Adenosine 3',5

规格或纯度：99%

英文名称：Adenosine 3′,5′-cyclic monophosphate

生化机理：Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍cAMP依赖的蛋白激酶(PKA)的激动剂。cAMP是许多系统至神经递质或荷尔蒙诱导的受体刺激的第二信使， cAMP/PKA信号途径可以抑制细胞扩增、诱导分化和导致细胞凋亡。应用腺苷3′,5′-环一磷酸已用于在胚胎脊髓神经细胞培养中作为细胞培养基补充剂作为灌注研究中林格溶液的一个组成部分在人肺癌细胞系中诱导神经内分泌分化Product ApplicationAdenosine 3′,5′-cyclic monophosphate has been usedas cell culture medium supplement in embryonic spinal neuronsas a component of ringer solution for perfusion studiesto induce neuroendocrine differentiation in human lung cancer cell lines

IUPAC Name：(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

INCHI：InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

InChi Key：IVOMOUWHDPKRLL-KQYNXXCUSA-N

Canonical SMILES：C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O

Isomeric SMILES：C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O

WGK Germany：3

RTECS：AU7357600

关联CAS：60-92-4,37839-81-9 (mono-hydrochloride salt)

PubChem CID：6076

MeSH Entry Terms：3',5'-Monophosphate, Adenosine Cyclic;Adenosine Cyclic 3',5' Monophosphate;Adenosine Cyclic 3',5'-Monophosphate;Adenosine Cyclic 3,5 Monophosphate;Adenosine Cyclic Monophosphate;Adenosine Cyclic-3',5'-Monophosphate;AMP, Cyclic;Cyclic 3',5'-Monophosphate,

Reaxy-Rn：52645

溶解性：H2O 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)；Solube in water 10 mg/mL pH of aqueous solution is approx. 3.0.；

密度：2.47

敏感性：对热敏感

比旋光度：-50° (C=0.7,H2O)

熔点：260°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH314 Causes severe skin burns and eye damageH318 Causes serious eye damage

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P301+P330+P331,P304+P340,P363,P403+P233,P362+P364,P264+P265,P305+P354+P338,P317,P337+P317,P332+P317,P302+P361+P354,P316,P319

Merck Index：2708

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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