产品名称

英文名称：Doxorubicin hydrochloride

同义词

Doxorubicin Hydrochloride、25316-40-9、Doxorubicin HCl、Rubex、Adriacin、Adriblastina、Hydroxydaunorubicin hydrochloride、Caelyx、Doxil、ADRIAMYCIN HYDROCHLORIDE、Adriamycin PFS、Adriamycin RDF、ADRIAMYCIN, HYDROCHLORIDE、Doxorubicin (Adriamycin) HCl、Adrosal、Duxocin、A、盐酸多柔比星、羟基柔红霉素盐酸盐、阿霉素盐酸盐、多柔比星盐酸盐、阿霉素

产品性质

CAS编号：25316-40-9

分子式：C27H29NO11·HCl

分子量：579.98

Beilstein号：4229251

EC号：246-818-3

MDL号：MFCD00077757

PubChem编号：443939

别名：盐酸多柔比星|羟基柔红霉素盐酸盐|阿霉素盐酸盐|多柔比星盐酸盐|阿霉素

英文别名：Doxorubicin Hydrochloride|25316-40-9|Doxorubicin HCl|Rubex|Adriacin|Adriblastina|Hydroxydaunorubicin hydrochloride|Caelyx|Doxil|ADRIAMYCIN HYDROCHLORIDE|Adriamycin PFS|Adriamycin RDF|ADRIAMYCIN, HYDROCHLORIDE|Doxorubicin (Adriamycin) HCl|Adrosal|Duxocin|A

规格或纯度：98%

英文名称：Doxorubicin hydrochloride

生化机理：Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sμgar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.

应用：抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.A Topo II inhibitor, DNA intercalator and powerful cytotoxic agent

IUPAC Name：(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

INCHI：InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChi Key：MWWSFMDVAYGXBV-RUELKSSGSA-N

Canonical SMILES：CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

Isomeric SMILES：C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

WGK Germany：3

RTECS：QI9295900

PubChem CID：443939

Reaxy-Rn：4229251

溶解性：溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度 10 mg/mL, 水溶液为橙红色透明溶液。,

敏感性：对光和湿度和热敏感

比旋光度：+240 to +270 deg(C=0.1,MeOH)

熔点：216°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH302 Harmful if swallowedH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancer

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P270,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317

Merck Index：3439

个人防护装备：Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装