产品名称

英文名称：NPS-2143

同义词

NPS-2143、284035-33-2、NPS 2143、SB-262470、NPS2143、(+)-NPS-2143、SB262470、CHEMBL180672、Z25PJ77W7V、2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE、SB-262470A、NPS-2143(SB 262470A )、Benzonitrile, 2-chloro-6-((2R)-3-

产品性质

CAS编号：284035-33-2

分子式：C24H25ClN2O2

分子量：408.93

PubChem编号：6918446

英文别名：NPS-2143|284035-33-2|NPS 2143|SB-262470|NPS2143|(+)-NPS-2143|SB262470|CHEMBL180672|Z25PJ77W7V|2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE|SB-262470A|NPS-2143(SB 262470A )|Benzonitrile, 2-chloro-6-((2R)-3-

规格或纯度：≥98%

英文名称：NPS-2143

生化机理：NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH [1]. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH .

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：NPS-2143(SB 262470A)是选择性的Ca(2+)受体拮抗剂，IC50为43 nM。NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.

IUPAC Name：2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile

INCHI：InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1

InChi Key：PZUJQWHTIRWCID-HXUWFJFHSA-N

Canonical SMILES：CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O

Isomeric SMILES：CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O

PubChem CID：6918446

ChEMBL Ligand：CHEMBL180672

CAS Registry No.：284035-33-2

Wikipedia：NPS-2143

Antibiotic DB：1569

RCSB PDB Ligand：YP1

GPCRdb Ligand：NPS 2143

溶解性：DMSO 82 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装