产品名称

英文名称：Forskolin

同义词

forskolin、Colforsin、66575-29-9、Coleonol、colforsina、colforsine、colforsinum、Boforsin、HL 362、Coleonolk、L 75 1362B、(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate、Forskolin、佛司可林、毛喉素、7β-乙酰氧基-8,13--环氧-1α,6β,9α-三羟基labd-14-烯-11-酮、考福新、洋紫苏醇

产品性质

CAS编号：66575-29-9

分子式：C22H34O7

分子量：410.5

Beilstein号：1692720

MDL号：MFCD00082317

PubChem编号：47936

别名：佛司可林|毛喉素|7β-乙酰氧基-8,13--环氧-1α,6β,9α-三羟基labd-14-烯-11-酮|考福新|洋紫苏醇

英文别名：forskolin|Colforsin|66575-29-9|Coleonol|colforsina|colforsine|colforsinum|Boforsin|HL 362|Coleonolk|L 75 1362B|(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate|Forskolin

规格或纯度：≥98%

英文名称：Forskolin

生化机理：Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet antiaggregatory and antihypertensive actions in vivo .

应用：An adenylate cyclase activator and MAP kinase inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Forskolin是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，常用来提高cAMP水平。An adenylate cyclase activator and MAP kinase inhibitorForskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC), commonly used to raise levels of cAMP in the study and research of cell physiology.An adenylate cyclase activator and MAP kinase inhibitor

IUPAC Name：[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate

INCHI：InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChi Key：OHCQJHSOBUTRHG-KGGHGJDLSA-N

Canonical SMILES：CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O

Isomeric SMILES：CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

WGK Germany：3

RTECS：QL6150000

PubChem CID：47936

CAS Registry No.：66575-29-9

DrugBank Ligand：DB02587

Wikipedia：Forskolin

ChEBI：CHEBI42471

ChEMBL Ligand：CHEMBL52606

RCSB PDB Ligand：FOK

溶解性：Soluble in DMSO (5 mg/ml), ethanol, methanol, and Chloroform.Insolule in water.

比旋光度：-17°

熔点：224.0 to 228.0°C

象形图：

信号词：Warning

危险声明：H312 Harmful in contact with skin

预防措施声明：P280,P302+P352,P321,P501,P362+P364,P317

Merck Index：2476

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装