产品名称

英文名称：Candesartan

同义词

candesartan 、 HTQMVQVXFRQIKW-UHFFFAOYSA-N 、 [3H]candesartan 、 CANDESARTAN CILEXETIL IMPURITY G [EP IMPURITY] 、 NCGC00167474-04 、 C-266 、 1-[(2 inverted exclamation mark -(5-Tetrazolyl)-4-biphenylyl)methyl]-2-ethoxybenzimidazole-7-carboxylic Acid 、 BCPP000、坎地沙坦 、 坎地沙坦酯相关化合物G

产品性质

CAS编号：139481-59-7

分子式：C24H20N6O3

分子量：440.45

EC号：604-138-8

PubChem编号：2541

别名：坎地沙坦 | 坎地沙坦酯相关化合物G

英文别名：candesartan | HTQMVQVXFRQIKW-UHFFFAOYSA-N | [3H]candesartan | CANDESARTAN CILEXETIL IMPURITY G [EP IMPURITY] | NCGC00167474-04 | C-266 | 1-[(2 inverted exclamation mark -(5-Tetrazolyl)-4-biphenylyl)methyl]-2-ethoxybenzimidazole-7-carboxylic Acid | BCPP000

规格或纯度：≥99%

英文名称：Candesartan

生化机理：血管紧张素II受体1（AT1）拮抗剂（牛肾上腺皮质和兔主动脉的IC50值分别为1.12和2.86 nM）。在动物模型中表现出降压作用。candesartan cilexetil也可以作为前药获得。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Candesartan 是angiotensin II(血管紧张素II)受体拮抗剂， IC50为0.26 nM。A selective angiotensin II receptor antagonist.Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.A selective angiotensin II receptor antagonist.ApplicationCAN may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatography techniques.These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

ALogP：4.1

IUPAC Name：2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

INCHI：InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)

InChi Key：HTQMVQVXFRQIKW-UHFFFAOYSA-N

Canonical SMILES：CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O

Isomeric SMILES：CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O

关联CAS：139481-59-7

PubChem CID：2541

NSC Number：759858

MeSH Entry Terms：2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid;2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole;candesartan;CV 11974;CV-11974;CV11974

DrugBank Ligand：DB00796

CAS Registry No.：139481-59-7

ChEBI：CHEBI3347

Wikipedia：Candesartan

BindingDB Ligand：50240609

ChEMBL Ligand：CHEMBL1016

PEP：candesartan

Reactome Reaction：R-HSA-9615249

Reactome Drug：R-ALL-9615297

GPCRdb Ligand：candesartan

溶解性：Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C)

凝固点：183-185°C

象形图：

信号词：Warning

危险声明：H400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P391,P203,P318

产品包装