产品名称

英文名称：Ataluren (PTC124)

同义词

(Z)-4-oxo-4-((4-phenylthiazol-2(3H)-ylidene)amino)butanoic acid、Ataluren(ptc124)、BCP01756、HMS3656H20、PTC124;3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid;PTC-124、DTXCID3026776、Ataluren、Ataluren [USAN]、K16AME9I3V、3-[5-(2-Fluorophenyl)-1,2,4-oxadi、阿塔鲁伦

产品性质

CAS编号：775304-57-9

分子式：C15H9FN2O3

分子量：284.24

PubChem编号：11219835

别名：阿塔鲁伦

英文别名：(Z)-4-oxo-4-((4-phenylthiazol-2(3H)-ylidene)amino)butanoic acid|Ataluren(ptc124)|BCP01756|HMS3656H20|PTC124;3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid;PTC-124|DTXCID3026776|Ataluren|Ataluren [USAN]|K16AME9I3V|3-[5-(2-Fluorophenyl)-1,2,4-oxadi

规格或纯度：≥99%

英文名称：Ataluren (PTC124)

生化机理：PTC124 has been shown to selectively induce ribosomal read-throμgh of premature termination but not normal termination codons during mRNA translation. This compound has been reported to promote dystrophin production in primary muscle cells. Additionally, PTC124 has been shown to induce cAMP-stimulated transepithelial chloride currents in the murine apical surface of intestinal glands. Other experiments sμggest that this agent is a potent inhibitor of firefly luciferase (FLuc).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg卖完停产，不再备货

产品介绍：Ataluren (PTC124)选择性诱导核糖体通读，不影响正常的终止密码子，EC50为0.1 μM，可以治疗nonsense mutations（无义突变） (如CFTR无义突变引起的囊性纤维病(CF))造成的遗传性疾病。A firefly luciferase inhibitor and an inducer of ribosomal read-throμgh of mRNAs.PTC124 (Ataluren) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation).A firefly luciferase inhibitor and an inducer of ribosomal read-through of mRNAs.

ALogP：3.1

PubChem SID：488197298

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488197298

IUPAC Name：3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid

INCHI：InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)

InChi Key：OOUGLTULBSNHNF-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

Isomeric SMILES：C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

PubChem CID：11219835

ChEMBL Ligand：CHEMBL256997

CAS Registry No.：775304-57-9

Wikipedia：Ataluren

DrugCentral Ligand：4872

RCSB PDB Ligand：JBF

溶解性：Soluble in DMSO (57 mg/ml), water (<1 mg/mL), and ethanol (<1 mg/mL).

熔点：242°C

产品包装