产品名称

英文名称：TAE684 (NVP-TAE684)

同义词

761439-42-3、NVP-TAE684、TAE684、NVP-TAE 684、TAE-684、5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine、TAE684 (NVP-TAE684)、TAE 684、NVT-TAE-684、5-Chloro-N2-[2-methoxy-4-[4-(4-meth

产品性质

CAS编号：761439-42-3

分子式：C30H40ClN7O3S

分子量：614.2

PubChem编号：16038120

英文别名：761439-42-3|NVP-TAE684|TAE684|NVP-TAE 684|TAE-684|5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine|TAE684 (NVP-TAE684)|TAE 684|NVT-TAE-684|5-Chloro-N2-[2-methoxy-4-[4-(4-meth

规格或纯度：≥98%

英文名称：TAE684 (NVP-TAE684)

生化机理：TAE684 selectively inhibits the phosphorylation of NPM-ALK, inducing apoptosis and G1 phase arrest in Ba/F3 cell lines. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation of NPM-ALK-expressing human ALCL cell lines including Karpas-299 and SU-DHL-1 with IC50 of 2–5 nM.Highly potent, selective ALK inhibitor in vitro (IC 50 = 2 nM). Suppresses lymphomagenesis in vivo . Down-regulates CD30 expression. Antitumor agent. Potent LRRK2 kinase inhibitor (IC 50 = 7.8 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：TAE684 (NVP-TAE684)是一种有效的，选择性的ALK抑制剂，IC50为3 nM，作用于ALK比作用于InsR选择性高100倍。A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 KinaseTAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM, 100-fold more sensitive for ALK than InsR.A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase

IUPAC Name：5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

INCHI：InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)

InChi Key：QQWUGDVOUVUTOY-UHFFFAOYSA-N

Canonical SMILES：CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

Isomeric SMILES：CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

PubChem CID：16038120

CAS Registry No.：761439-42-3

DiscoveRx TREEspot：TAE-684|

ChEMBL Ligand：CHEMBL509032

RCSB PDB Ligand：GUI

溶解性：DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装