产品名称

英文名称：PHA-767491

同义词

PHA-767491、845714-00-3、PHA 767491、2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one、CAY10572、1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one、CAY10572(PHA-767491)、5M2GUN688C、2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin

产品性质

CAS编号：845714-00-3

分子式：C12H11N3O

分子量：213.24

PubChem编号：11715767

英文别名：PHA-767491|845714-00-3|PHA 767491|2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one|CAY10572|1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one|CAY10572(PHA-767491)|5M2GUN688C|2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin

规格或纯度：≥98%

英文名称：PHA-767491

生化机理：PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Cdc7 kinase is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. At 10 μM, PHA-767491 induces apoptotic cell death in multiple cancer cell types. PHA-767491 also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression.Potent Cdc7 and Cdk9 kinase inhibitor (IC 50 values are 10 and 34 nM for Cdc7 in the presence of 1.5 µM ATP and Cdk9 respectively). Induces apoptosis in cancer cell lines. Shows synergistic antitumor effects in vivo with 5-fluorouracil.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PHA-767491 (CAY10572)是ATP竞争性Cdc7和Cdk9抑制剂，IC50分别为10 nM和34 nM。A potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM. IC50 Value 10 nM(Cdc7); 34 nM(Cdk9)A potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9

IUPAC Name：2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

INCHI：InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)

InChi Key：DKXHSOUZPMHNIZ-UHFFFAOYSA-N

Canonical SMILES：C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3

Isomeric SMILES：C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3

关联CAS：845714-00-3

PubChem CID：11715767

MeSH Entry Terms：PHA 767491;PHA-767491;PHA767491

溶解性：DMSO 24 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装