产品名称

英文名称：CP-101,606

同义词

Traxoprodil、134234-12-1、1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol、CP-101,606、Traxoprodil [INN]、CP 101606、Traxoprodil mesylate、CP-101606、1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol、UTC046R5H

产品性质

CAS编号：134234-12-1

分子式：C20H25NO3

分子量：327.42

PubChem编号：219101

英文别名：Traxoprodil|134234-12-1|1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol|CP-101,606|Traxoprodil [INN]|CP 101606|Traxoprodil mesylate|CP-101606|1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol|UTC046R5H

规格或纯度：98% (HPLC)

英文名称：CP-101,606

生化机理：Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke. CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders. Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.Traxoprodil (CP101,606) 是一种有效的和选择性的 NMDA 拮抗剂，保护海马神经元的 IC50 值为10 nM。CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.

ALogP：2.3

IUPAC Name：1-[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol

INCHI：InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

InChi Key：QEMSVZNTSXPFJA-HNAYVOBHSA-N

Canonical SMILES：CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O

Isomeric SMILES：C[C@@H]([C@H](C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O

WGK Germany：3

PubChem CID：219101

Wikipedia：Traxoprodil

CAS Registry No.：134234-12-1

ChEMBL Ligand：CHEMBL17350

溶解性：二甲基亚砜≥35毫克/毫升

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowedH400 Very toxic to aquatic life

预防措施声明：P305+P351+P338,P273,P280,P321,P405,P501,P264,P270,P391,P330,P264+P265,P301+P316,P337+P317

产品包装