产品名称

英文名称：R406 (free base)

同义词

841290-80-0、tamatinib、R-406、R406 (free base)、R406 free base、6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one、Tamatinib free base、6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino

产品性质

CAS编号：841290-80-0

分子式：C22H23FN6O5

分子量：470.45

PubChem编号：11213558

英文别名：841290-80-0|tamatinib|R-406|R406 (free base)|R406 free base|6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one|Tamatinib free base|6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino

规格或纯度：≥99%

英文名称：R406 (free base)

生化机理：R406(free base) is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg、10mg卖完停产，不再备货

产品介绍：R406 (free base)是一种有效的Syk抑制剂,IC50为41 nM,强效抑制Syk而不能抑制Lyn,对Flt3作用效果低5倍。R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3.

ALogP：3.1

IUPAC Name：6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

INCHI：InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)

InChi Key：NHHQJBCNYHBUSI-UHFFFAOYSA-N

Canonical SMILES：CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C

Isomeric SMILES：CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C

PubChem CID：11213558

CAS Registry No.：841290-80-0

DiscoveRx TREEspot：R406|

ChEMBL Ligand：CHEMBL475251

RCSB PDB Ligand：585

Reactome Reaction：R-HSA-9702508, R-HSA-9695828, R-HSA-9703008

Reactome Drug：R-ALL-9702985

溶解性：DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338

产品包装