产品名称

英文名称：betrixaban

同义词

EN300-18167087、Benzamide, N-(5-chloro-2-pyridinyl)-2-((4-((dimethylamino)iminomethyl)benzoyl)amino)-5-methoxy-、BETRIXABAN [ORANGE BOOK]、BCP9000395、Bevyxxa、compound 11 [PMID 19297154]、FT-0663094、DB12364、DTXSID30903075、EX-A358、BETRIXABAN [INN]、s5388、compou、贝曲西班

产品性质

CAS编号：330942-05-7

分子式：C23H22ClN5O3

分子量：451.91

PubChem编号：10275777

别名：贝曲西班

英文别名：EN300-18167087|Benzamide, N-(5-chloro-2-pyridinyl)-2-((4-((dimethylamino)iminomethyl)benzoyl)amino)-5-methoxy-|BETRIXABAN [ORANGE BOOK]|BCP9000395|Bevyxxa|compound 11 [PMID 19297154]|FT-0663094|DB12364|DTXSID30903075|EX-A358|BETRIXABAN [INN]|s5388|compou

规格或纯度：97%

英文名称：betrixaban

生化机理：Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 μM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 μM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Betrixaban (PRT054021) 是一种有效的，具有口服活性的选择性 factor Xa (fXa) 抑制剂，IC50 为1.5 nM。Product DescriptionBetrixaban (PRT054021) is ahighly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with IC50 of 1.5 nM

ALogP：3.6

IUPAC Name：N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide

INCHI：InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)

InChi Key：XHOLNRLADUSQLD-UHFFFAOYSA-N

Canonical SMILES：CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl

Isomeric SMILES：CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl

PubChem CID：10275777

ChEMBL Ligand：CHEMBL512351

BindingDB Ligand：50249298

CAS Registry No.：330942-05-7

Reactome Reaction：R-HSA-9015122, R-HSA-9015111

Reactome Drug：R-ALL-9038746

DrugCentral Ligand：5241

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowed

预防措施声明：P501,P264,P260,P270,P330,P301+P317,P319

产品包装