产品名称

英文名称：LY2940680

同义词

Taladegib、1258861-20-9、LY2940680、LY-2940680、4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide、LY 2940680、QY8BWX1LJ5、LY-2940680(Taladegib)、Taladegib (LY2940680)、4-fluoro-N-methyl-N-[1-[4-(2-met

产品性质

CAS编号：1258861-20-9

分子式：C26H24F4N6O

分子量：512.5

PubChem编号：49848070

英文别名：Taladegib|1258861-20-9|LY2940680|LY-2940680|4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide|LY 2940680|QY8BWX1LJ5|LY-2940680(Taladegib)|Taladegib (LY2940680)|4-fluoro-N-methyl-N-[1-[4-(2-met

规格或纯度：≥99%

英文名称：LY2940680

生化机理：强大的刺猬信号通路抑制剂。平滑的拮抗剂。抑制含有与疾病相关的\ xa0平滑基因突变的癌细胞系的生长。在动物模型中具有抗肿瘤活性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：LY2940680与Smoothened(Smo)受体结合，有效抑制Hedgehog(Hh)信号通路。Phase 1/2。LY2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.

ALogP：4.3

IUPAC Name：4-fluoro-N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoromethyl)benzamide

INCHI：InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3

InChi Key：SZBGQDXLNMELTB-UHFFFAOYSA-N

Canonical SMILES：CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F

Isomeric SMILES：CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F

PubChem CID：49848070

CAS Registry No.：1258861-20-9

ChEMBL Ligand：CHEMBL2142592

RCSB PDB Ligand：1KS

GPCRdb Ligand：taladegib

溶解性：DMSO 0.66 mg/mL (1.28 mM); Water <1 mg/mL (<1 mM); Ethanol 2 mg/mL (3.9 mM)

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

产品包装