产品名称

英文名称：Abemaciclib (LY2835219)

同义词

1231930-82-7、Abemaciclib mesylate、Abemaciclib methanesulfonate、LY2835219 Mesylate、N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate、LY-2835219 methanesul

产品性质

CAS编号：1231930-82-7

分子式：C27H32F2N8.CH4O3S

分子量：602.7

PubChem编号：71576678

英文别名：1231930-82-7|Abemaciclib mesylate|Abemaciclib methanesulfonate|LY2835219 Mesylate|N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate|LY-2835219 methanesul

规格或纯度：≥98%

英文名称：Abemaciclib (LY2835219)

生化机理：LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：LY2835219对CDK4和CDK6的IC50分别为2 nM和10 nM。LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.

IUPAC Name：N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid

INCHI：InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)

InChi Key：NCJPFQPEVDHJAZ-UHFFFAOYSA-N

Canonical SMILES：CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

Isomeric SMILES：CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

PubChem CID：71576678

溶解性：DMSO 83 mg/mL Water 100 mg/mL Ethanol 24 mg/mL

产品包装