产品名称

英文名称：Palbociclib isethionate

同义词

Palbociclib Isethionate、827022-33-3、PD0332991 Isethionate、PD 0332991 isethionate、Palbociclib (PD0332991) Isethionate、UNII-W1NYL2IRDR、W1NYL2IRDR、Palbociclib (isethionate)、Palbociclib Isethionate [USAN]、6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)、帕博西尼羟乙基磺酸盐、帕布西利布羟基乙磺酸盐、6-乙酰基-8-环戊基-5-甲基-2 - [[5-(1-哌嗪基)-2-吡啶基]氨基]吡啶并[2,3-d]嘧啶-7(8H) - 酮2-羟基 - 乙磺酸(11)

产品性质

CAS编号：827022-33-3

分子式：C24H29N7O2·C2H6O4S

分子量：573.66

MDL号：MFCD22666589

PubChem编号：11478676

别名：帕博西尼羟乙基磺酸盐|帕布西利布羟基乙磺酸盐|6-乙酰基-8-环戊基-5-甲基-2 - [[5-(1-哌嗪基)-2-吡啶基]氨基]吡啶并[2,3-d]嘧啶-7(8H) - 酮2-羟基 - 乙磺酸(11)

英文别名：Palbociclib Isethionate|827022-33-3|PD0332991 Isethionate|PD 0332991 isethionate|Palbociclib (PD0332991) Isethionate|UNII-W1NYL2IRDR|W1NYL2IRDR|Palbociclib (isethionate)|Palbociclib Isethionate [USAN]|6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)

规格或纯度：98%

英文名称：Palbociclib isethionate

生化机理：PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells. PD 0332991 might act as a chemsensitizer. It is useful in the treatment of breast cancer along with antioestrogens. PD 0332991 is also known to possess antitumor action.Highly selective, potent,\xa0CDK4/6 inhibitor (IC 50 = 11 nM/16 nM in cell-free assays). No activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. Displays anti-cancer chemotherapeutic and nephroprotective activities.

法律信息：Sold for only research purposes

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，IC50为11 nM/16 nM，对CDK1/2/5， EGFR， FGFR， PDGFR， InsR等没有抑制活性。Phase 3。Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

IUPAC Name：6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;2-hydroxyethanesulfonic acid

INCHI：InChI=1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)

InChi Key：LYYVFHRFIJKPOV-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O

Isomeric SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O

WGK Germany：3

PubChem CID：11478676

溶解性：DMSO <1 mg/mL (<1 mM); Water 50 mg/mL heating (87.15 mM); Ethanol <1 mg/mL (<1 mM)

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P301+P310

产品包装