产品名称

英文名称：Alvelestat

同义词

848141-11-7、Alvelestat、Alvelestat (AZD9668)、Alvelestat [INN]、Alvelestat; AZD 9668、avelestat-azd9668、AZD 9668、AZD-9668、AZD9668、AZD9668;AZD-9668;AZD 9668、Alvelestat (AZD9688)、MPH966、6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)me

产品性质

CAS编号：848141-11-7

分子式：C25H22F3N5O4S

分子量：545.53

PubChem编号：46861623

英文别名：848141-11-7|Alvelestat|Alvelestat (AZD9668)|Alvelestat [INN]|Alvelestat; AZD 9668|avelestat-azd9668|AZD 9668|AZD-9668|AZD9668|AZD9668;AZD-9668;AZD 9668|Alvelestat (AZD9688)|MPH966|6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)me

规格或纯度：≥98%

英文名称：Alvelestat

生化机理：Alvelestat (AZD9668) is a novel oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7 9 for Human NE.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Alvelestat (AZD9668)是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.

ALogP：2.5

IUPAC Name：6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide

INCHI：InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)

InChi Key：QNQZWEGMKJBHEM-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C

Isomeric SMILES：CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C

PubChem CID：46861623

CAS Registry No.：848141-11-7

溶解性：25°C DMSO

产品包装