产品名称

英文名称：Cabotegravir

同义词

Cabotegravir、1051375-10-0、GSK1265744、GSK744、GSK-1265744、GSK1265744A、S-265744、GSK744 LAP、GSK-1265744A、GSK744 LA、Cabotegravir (GSK744, GSK1265744)、GSK 744、S/GSK1265744、GSK 1265744、HMH0132Z1Q、(3S,11AR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,

产品性质

CAS编号：1051375-10-0

分子式：C19H17F2N3O5

分子量：405.3522

PubChem编号：54713659

英文别名：Cabotegravir|1051375-10-0|GSK1265744|GSK744|GSK-1265744|GSK1265744A|S-265744|GSK744 LAP|GSK-1265744A|GSK744 LA|Cabotegravir (GSK744, GSK1265744)|GSK 744|S/GSK1265744|GSK 1265744|HMH0132Z1Q|(3S,11AR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,

规格或纯度：97%

英文名称：Cabotegravir

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Cabotegravir (GSK744, GSK1265744, S/GSK1265744)是一种长效HIV integrase抑制剂，作用于广泛的HIV亚型，抑制了HIV-1 integrase 催化的链转移反应的IC50为3 nMCabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.

ALogP：2.1

IUPAC Name：(3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide

INCHI：InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1

InChi Key：WCWSTNLSLKSJPK-LKFCYVNXSA-N

Canonical SMILES：CC1COC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

Isomeric SMILES：C[C@H]1CO[C@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

PubChem CID：54713659

CAS Registry No.：1051375-10-0

ChEMBL Ligand：CHEMBL2403238

BindingDB Ligand：50492496

DrugBank Ligand：DB11751

溶解性：Chloroform (Slightly, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly, Heated)

熔点：248-251ºC

象形图：

信号词：Warning

危险声明：H400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P501,P391

产品包装