产品名称

英文名称：Urokinase from human urine

同义词

Cambendazole、Cambendazol、26097-80-3、Novazole、Noviben、Bonlam、Camvet、Cambenzole、Camdan、Equiben、CBDZ、Urokinase、9039-53-6、MK 905、NSC 377071、NSC-377071、Isopropyl 2-(4-triazolyl)-5-benzimidazolecarbamate、DTXSID0046852、079X63S3DU、5-BENZIMIDAZOLECARBAMIC ACID, 2-

产品性质

CAS编号：9039-53-6

EC号：232-917-9

MDL号：MFCD00132566

PubChem编号：33309

英文别名：Cambendazole|Cambendazol|26097-80-3|Novazole|Noviben|Bonlam|Camvet|Cambenzole|Camdan|Equiben|CBDZ|Urokinase|9039-53-6|MK 905|NSC 377071|NSC-377071|Isopropyl 2-(4-triazolyl)-5-benzimidazolecarbamate|DTXSID0046852|079X63S3DU|5-BENZIMIDAZOLECARBAMIC ACID, 2-

规格或纯度：≥85%,效价≥5万IU/mg，比活≥12万IU/mg

英文名称：Urokinase from human urine

生化机理：Urokinase expression and invasiveness suppression by urinary trypsin inhibitor acts throμgh MEK/ERK/c-Jun-dependent signaling pathways

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。主要活性成分是尿激酶的低分子量形式，由 2,000 道尔顿的 A 链和 30,400 道尔顿的 B 链通过巯基键连接而成。产品应用人肾细胞产生的尿激酶已被用作消化混合物的成分，用于三维纤维蛋白培养。也用于纤溶酶原激活试验。生理学机理尿激酶可促进肾肿瘤细胞的增殖。尿激酶是一种蛋白酶，能裂解纤溶酶原形成纤溶酶。与细胞表面受体 (uPAR) 结合，在组织重塑过程中调节细胞粘附和迁移，并激活细胞内信号通路。尿激酶由三个结构域组成与表皮生长因子同源的氨基末端结构域通过中央圈形区结构域连接到羧基端的蛋白酶结构域。Physical form Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol Physical properties High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditionsUrokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.

PubChem SID：488183221

IUPAC Name：propan-2-yl N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]carbamate

INCHI：InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)

InChi Key：QZWHWHNCPFEXLL-UHFFFAOYSA-N

Canonical SMILES：CC(C)OC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3

Isomeric SMILES：CC(C)OC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3

WGK Germany：3

RTECS：OB8900000

PubChem CID：33309

敏感性：对湿度敏感

象形图：

信号词：Warning

危险声明：H361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

产品包装