产品名称

英文名称：Toremifene

同义词

涛瑞米芬

产品性质

CAS编号：89778-26-7

分子式：C26H28ClNO

分子量：405.96

PubChem编号：3005573

别名：涛瑞米芬

规格或纯度：98%

英文名称：Toremifene

生化机理：IC50 Value 1±0.3μM. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT in men with prostate cancer [1]. in vitro The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[2]. in vivo The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[2]. Clinical trial Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene[3].Competitive, irreversible estrogen biosynthesis inhibitor. Tamoxifen analog. Shows antitumor effects in vivo . Reduces serum cholesterol, low-density lipoprotein cholesterol and triglycerides following ovariectomy. Orally active. Cell-permeab

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

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产品介绍：产品介绍Toremifene (Z-Toremifene) 是第二代选择性雌激素受体调节剂。Toremifene 还可以有效抑制传染性 EBOV Zaire 和 Marburg (MARV)。

IUPAC Name：2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

INCHI：InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-

InChi Key：XFCLJVABOIYOMF-QPLCGJKRSA-N

Canonical SMILES：CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3

Isomeric SMILES：CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3

PubChem CID：3005573

DrugBank Ligand：DB00539

Wikipedia：Toremifene

ChEBI：CHEBI9635

CAS Registry No.：89778-26-7

ChEMBL Ligand：CHEMBL1655

RCSB PDB Ligand：T0R

DrugCentral Ligand：2709

溶解性：25°C DMSO 120mg/mL ;Water <1mg/mL; Ethanol <1mg/mL

敏感性：对光线敏感

产品包装