产品名称

英文名称：Penicillic acid

同义词

penicillic acid、90-65-3、2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-、(2Z)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid、Pencillic acid、Kyselina penicilova、3-Methoxy-5-methyl-4-oxohexa-2,5-dienoic acid、Penicillinsaure、MFCD00004365、SCHEMBL148669、SCHEMBL8

产品性质

CAS编号：90-65-3

分子式：C8H10O4

分子量：170.16

EC号：202-008-1

MDL号：MFCD00004365

PubChem编号：1268111

英文别名：penicillic acid|90-65-3|2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-|(2Z)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid|Pencillic acid|Kyselina penicilova|3-Methoxy-5-methyl-4-oxohexa-2,5-dienoic acid|Penicillinsaure|MFCD00004365|SCHEMBL148669|SCHEMBL8

规格或纯度：≥98% (HPLC)

英文名称：Penicillic acid

生化机理：Penicillic acid is a mycotoxin isolated from various strains of Penicillium and Aspergillus fungi that demonstrates mutagenic and cytotoxic effects. This compound is demonstrated to induce single-strand DNA breaks and to inhibit DNA synthesis in CHO cells. Penicillic acid is also reported to irreversibly inactivate GMD (GDP-mannose dehydrogenase), interrupting the committed step in alginate biosynthesis. Penicillic acid is an inhibitor of ADH/AKR1A1 and LDH.Mutagen. Antibiotic mycotoxin. Induces DNA single-strand breaks. Irreversible GDP-mannose dehydrogenase inhibitor. Inhibits RNA and protein synthesis (ED 50 values are 180 and 600 μM respectively). Glutathione S-transferase inhibitor.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Penicillic acid 是由几种曲霉菌和青霉菌产生的一种聚酮化合物霉菌毒素，在体外对大鼠肺泡巨噬细胞 (AM) 具有细胞毒性。Penicillic acid 通过阻断 caspase-8 自我加工来抑制 Fas 配体诱导的细胞凋亡 Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.

IUPAC Name：(2Z)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid

INCHI：InChI=1S/C8H10O4/c1-5(2)8(11)6(12-3)4-7(9)10/h4H,1H2,2-3H3,(H,9,10)/b6-4-

InChi Key：VOUGEZYPVGAPBB-XQRVVYSFSA-N

Canonical SMILES：CC(=C)C(=O)C(=CC(=O)O)OC

Isomeric SMILES：CC(=C)C(=O)/C(=C/C(=O)O)/OC

WGK Germany：3

PubChem CID：1268111

溶解性：Soluble in water (50 mg/ml), DMSO (>10 mg/ml), chloroform (10 mg/ml), ethyl acetate (>10 mg/ml), and acetonitrile (>10 mg/ml)

敏感性：对湿度敏感

熔点：83°C-87°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装