产品名称

英文名称：N-p-Tosyl-L-phenylalanine chloromethyl ketone

同义词

TPCK、402-71-1、TOSYLPHENYLALANYL CHLOROMETHYL KETONE、N-Tosyl-L-phenylalanyl chloromethyl ketone、N-Tosyl-L-phenylalanine chloromethyl ketone、Tos-Phe-CH2Cl、N-p-Tosyl-L-phenylalanine chloromethyl ketone、L-1-Tosylamido-2-phenylethyl chloromethyl ketone、(S)-N-(、TPCK、甲苯磺酰基-L-氨基联苯氯甲基酮、(S)-N-(4-氯-3-氧代-1-苯基-2-丁基)对甲苯磺酰胺、N-对-甲苯磺酰基-L-苯基乙基氯甲基酮、(S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮、L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮、(S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮

产品性质

CAS编号：402-71-1

分子式：C17H18ClNO3S

分子量：351.85

Beilstein号：2895215

EC号：206-954-6

MDL号：MFCD00000935

PubChem编号：439647

别名：TPCK|甲苯磺酰基-L-氨基联苯氯甲基酮|(S)-N-(4-氯-3-氧代-1-苯基-2-丁基)对甲苯磺酰胺|N-对-甲苯磺酰基-L-苯基乙基氯甲基酮|(S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮|L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮|(S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮

英文别名：TPCK|402-71-1|TOSYLPHENYLALANYL CHLOROMETHYL KETONE|N-Tosyl-L-phenylalanyl chloromethyl ketone|N-Tosyl-L-phenylalanine chloromethyl ketone|Tos-Phe-CH2Cl|N-p-Tosyl-L-phenylalanine chloromethyl ketone|L-1-Tosylamido-2-phenylethyl chloromethyl ketone|(S)-N-(

规格或纯度：97%

英文名称：N-p-Tosyl-L-phenylalanine chloromethyl ketone

生化机理：Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).Irreversible chymotrypsin inhibitor and SMase inhibitor. Inhibits the activation of PDK1-dependent AGC kinases. Selectively inhibits RSK, Akt and S6K1. Shows antitumor effects in vivo.

应用：某些丝氨酸蛋白酶的不可逆抑制剂，用于在制备胰蛋白酶时抑制胰凝乳蛋白酶。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：不可逆的丝氨酸蛋白酶抑制剂,抑制胰蛋白酶样丝氨酸蛋白酶,包括菠萝蛋白酶,糜蛋白酶,无花果蛋白酶及木瓜蛋白酶。工作液稳定期为几个小时,贮存液(10mM甲醇溶液)在4°C下可保持稳定几个月。某些丝氨酸蛋白酶的不可逆抑制剂，用于在制备胰蛋白酶时抑制胰凝乳蛋白酶。N-p-Tosyl-L-phenylalanine chloromethyl ketone has been used to investigate whether transcription factor NFκB is involved in renalase expression to test the role of NF-κB activation to study its inhibitory effect on chymotrypsin

PubChem SID：488189751

IUPAC Name：N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide

INCHI：InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1

InChi Key：MQUQNUAYKLCRME-INIZCTEOSA-N

Canonical SMILES：CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl

Isomeric SMILES：CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl

RTECS：XT5613500

PubChem CID：439647

Reaxy-Rn：2895215

溶解性：DMSO >10 mg/mL (stable for several months at 4°C.) ethanol 20 mg/mL (stable for several months at 4°C. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4°C.)

敏感性：对热敏感

比旋光度：-87.0 to -91.0 deg(C=1, EtOH)

熔点：106.0 to 110.0 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH318 Causes serious eye damage

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P305+P354+P338,P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装