产品名称

英文名称：Phenylbutazone

同义词

phenylbutazone、50-33-9、4-Butyl-1,2-diphenylpyrazolidine-3,5-dione、Butapirazol、Butazolidin、Butadion、Diphenylbutazone、Butazolidine、Fenibutazona、Fenilbutazona、Fenylbutazon、Intrabutazone、Artrizin、Butacote、Butadiona、Diphebuzol、Ecobutazone、Fenibutol、Intrazone、P、保泰松、苯基丁氮酮

产品性质

CAS编号：50-33-9

分子式：C19H20N2O2

分子量：308.37

Beilstein号：24(5)5,400

MDL号：MFCD00005500

PubChem编号：4781

别名：保泰松|苯基丁氮酮

英文别名：phenylbutazone|50-33-9|4-Butyl-1,2-diphenylpyrazolidine-3,5-dione|Butapirazol|Butazolidin|Butadion|Diphenylbutazone|Butazolidine|Fenibutazona|Fenilbutazona|Fenylbutazon|Intrabutazone|Artrizin|Butacote|Butadiona|Diphebuzol|Ecobutazone|Fenibutol|Intrazone|P

规格或纯度：≥98%(HPLC)

英文名称：Phenylbutazone

生化机理：Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.Lipophilic NSAID. COX inhibitor. Reduces prostanoid-mediated edema. Shows analgesic and antipyretic effects in vivo.

应用：An inhibitor of Cox.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Phenylbutazone 是一种非甾体抗炎剂，用于治疗慢性疼痛，包括关节炎的症状。An inhibitor of Cox.Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.An inhibitor of Cox.

PubChem SID：488179856

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179856

IUPAC Name：4-butyl-1,2-diphenylpyrazolidine-3,5-dione

INCHI：InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3

InChi Key：VYMDGNCVAMGZFE-UHFFFAOYSA-N

Canonical SMILES：CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Isomeric SMILES：CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

WGK Germany：3

RTECS：UQ8225000

PubChem CID：4781

UN Number：2811

Packing Group：I

Reaxy-Rn：290080

DrugBank Ligand：DB00812

CAS Registry No.：50-33-9

ChEMBL Ligand：CHEMBL101

Wikipedia：Phenylbutazone

RCSB PDB Ligand：P1Z

DrugCentral Ligand：2145

溶解性：Soluble in water (1 mg/ml at 25 °C), ethanol (62 mg/ml at 25 °C), methanol, DMSO (62 mg/ml at 25 °C), and DMF (25 mg/ml).

熔点：106 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH351 Suspected of causing cancerH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P284,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P203,P264+P265,P301+P316,P318,P317,P337+P317,P332+P317,P319,P342+P316

Class：6.1

Merck Index：7277

个人防护装备：dust mask type N95 (US)， Eyeshields， Faceshields， Gloves

产品包装