产品名称

英文名称：Lercanidipine hydrochloride hemihydrate

同义词

Lercanidipine hydrochloride、132866-11-6、Lercanidipine HCl、Cardiovasc、Corifeo、Carmen、Lercadip、Lerzam、Lercan、LERCANIDIPINEHCL、Rec-15/2375、Lercanidipine (hydrochloride)、100427-27-8、3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-di

产品性质

CAS编号：132866-11-6

分子式：C36H41N3O6 · HCl · 0.5H2O

分子量：657.2

MDL号：MFCD07773089

PubChem编号：157917

英文别名：Lercanidipine hydrochloride|132866-11-6|Lercanidipine HCl|Cardiovasc|Corifeo|Carmen|Lercadip|Lerzam|Lercan|LERCANIDIPINEHCL|Rec-15/2375|Lercanidipine (hydrochloride)|100427-27-8|3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-di

规格或纯度：≥98% (HPLC)

英文名称：Lercanidipine hydrochloride hemihydrate

生化机理：L型Ca2 +通道阻滞剂显示出比非洛地平更高的血管选择性。导致外周血管舒张，仅具有弱的负性肌力活动。降压药。在体外细胞中也表现出抗MERS-CoV活性（IC50 = 2.36μM）。

应用：A calcium channel protein inhibitor

储存温度：2-8°C储存

运输条件：冰袋运输

备注：200mg、1g、10mg卖完停产，不再备货

产品介绍：Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine .A calcium channel protein inhibitorLercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine .A calcium channel protein inhibitor

IUPAC Name：5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

INCHI：InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H

InChi Key：WMFYOYKPJLRMJI-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl

Isomeric SMILES：CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl

WGK Germany：3

PubChem CID：157917

UN Number：2811

溶解性：溶于DMSO, 最高浓度 (mg/mL) 64.82, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 6.48, 最高浓度(mM) 10

敏感性：光敏,潮敏

熔点：195 °C(dec.)

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316,P301+P317

Merck Index：5446

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装