产品名称

英文名称：Clemastine Fumarate

同义词

CLEMASTINE FUMARATE、14976-57-9、Tavist、Agasten、Mecloprodine、Aloginan、Xolamin、Clemastine hydrogen fumarate、Alphamin、Anhistan、Clemanil、Fuluminol、Inbestan、Kinotomin、Lacretin、Maikohis、Marsthine、Masletine、Lecasol、Piloral、Reconin、Tavegil、Trabest、Mallermin-F、Telg、富马酸氯马斯汀、富马酸(R)-2-[2-[(R)-1-(4-氯苯基)-1-苯基乙氧基]乙基]-1-甲基吡咯烷

产品性质

CAS编号：14976-57-9

分子式：C21H26ClNO·C4H4O4

分子量：459.96

MDL号：MFCD00137486

PubChem编号：5281069

别名：富马酸氯马斯汀|富马酸(R)-2-[2-[(R)-1-(4-氯苯基)-1-苯基乙氧基]乙基]-1-甲基吡咯烷

英文别名：CLEMASTINE FUMARATE|14976-57-9|Tavist|Agasten|Mecloprodine|Aloginan|Xolamin|Clemastine hydrogen fumarate|Alphamin|Anhistan|Clemanil|Fuluminol|Inbestan|Kinotomin|Lacretin|Maikohis|Marsthine|Masletine|Lecasol|Piloral|Reconin|Tavegil|Trabest|Mallermin-F|Telg

规格或纯度：≥98% (HPLC)

英文名称：Clemastine Fumarate

生化机理：Clemastine fumarate is a selective histamine H1 Receptor antagonist with IC50 of 3 nM. Clemastine Fumarate inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM. Clemastine Fumarate significantly potentiates ATP-induced increase in [Ca2+]i in HEKhP2X7 cells not relying on histamine receptor blockage but on sensitizing P2X7 receptor.Potent and selective H 1 receptor antagonist (IC 50 = 3 nM). Potent HERG K + channel inhibitor (IC 50 = 12 nM). Allosteric modulator of P2X7. Shows immunosuppressant effects in vivo. Orally active.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Clemastine Fumarate是一种选择性组胺H1受体拮抗剂，IC50为3 nM。A selective histamine H1 antagonistClemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.A selective histamine H1 antagonistApplicationClemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

PubChem SID：488195227

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195227

IUPAC Name：(E)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

INCHI：InChI=1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChi Key：PMGQWSIVQFOFOQ-YKVZVUFRSA-N

Canonical SMILES：CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C.C(=CC(=O)O)C(=O)O

Isomeric SMILES：C[C@@](C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCC[C@H]3CCCN3C.C(=C/C(=O)O)\C(=O)O

WGK Germany：3

RTECS：UY0704600

PubChem CID：5281069

溶解性：Soluble in water (5 mM), methanol, DMSO (35 mg/ml), ethanol (3 mg/ml), and alcohol (slightly).

敏感性：对湿度敏感；对空气敏感

熔点：177-178°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P391,P330,P361+P364,P301+P316,P316

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