产品名称

英文名称：N-Hydroxysuccinimide

同义词

1-hydroxypyrrolidine-2,5-dione 、 1-Hydroxy-2,5-pyrrolidinedione 、 1-Hydroxysuccinimide 、 HOSu 、 Hydroxysuccinimide、N-羟基丁二酰亚胺 、 1-羟基-2,5-吡咯烷二酮

产品性质

CAS编号：6066-82-6

分子式：C4H5NO3

分子量：115.09

Beilstein号：113913

EC号：228-001-3

MDL号：MFCD00005516

PubChem编号：80170

别名：N-羟基丁二酰亚胺 | 1-羟基-2,5-吡咯烷二酮

英文别名：1-hydroxypyrrolidine-2,5-dione | 1-Hydroxy-2,5-pyrrolidinedione | 1-Hydroxysuccinimide | HOSu | Hydroxysuccinimide

规格或纯度：98%

英文名称：N-Hydroxysuccinimide

生化机理：胺反应性化合物。用于修饰，标记和交联胺基。用于蛋白质-蛋白质相互作用，N-末端残基鉴定以及磷酸化或O-糖基化残基位置的工具。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjμgation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.Useful in the carbodiimide method for improved amidations and peptide couplings. N-羟基琥珀酰亚胺可以在存在二环己基碳二亚胺的条件下在羧酸中通过脱水反应合成N-羟基琥珀酰亚胺酯。 N-羟基琥珀酰亚胺已用于中间介质的合成如 · N-丁二酰亚胺3-(二-三-丁基氟硅烷）苯甲酸 · 4-[2,2-双[(对-甲苯磺酰)-甲基]乙酰]苯甲酸-NHS酯 · N-丁二酰亚胺3-碘苯甲酸 它还用于微流体整合的表面等离子体共振（SPR）平台的微通道的表面修饰的实验方法中，用于对细菌病原体进行检测和定量。 碳二亚胺方法中使用的添加剂用于改良的酰胺化[1]及肽偶联。N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjugation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.Useful in the carbodiimide method for improved amidations and peptide couplings.

PubChem SID：488185823

IUPAC Name：1-hydroxypyrrolidine-2,5-dione

INCHI：InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChi Key：NQTADLQHYWFPDB-UHFFFAOYSA-N

Canonical SMILES：C1CC(=O)N(C1=O)O

Isomeric SMILES：C1CC(=O)N(C1=O)O

WGK Germany：3

PubChem CID：80170

Reaxy-Rn：113913

溶解性：Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

密度：1.649

敏感性：对热、湿度敏感

熔点：95-98°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品包装