产品名称

英文名称：Daphnetin

同义词

Spectrum4_001254、7,8-Dihydroxy-2H-1-benzopyran-2-one、XC84571RD2、KBio1_001904、ATEFPOUAMCWAQS-UHFFFAOYSA-N、BDBM50206006、BRD-K61269089-001-02-2、COUMARIN, 7,8-DIHYDROXY-、7,8-Dihydroxycoumarin, 90%、AE-641/02519040、NCGC00093770-02、NCGC00261015-01、Spectrum3_0007、瑞香素

产品性质

CAS编号：486-35-1

分子式：C9H6O4

分子量：178.14

Beilstein号：18(5)3,211

MDL号：MFCD00016977

PubChem编号：5280569

别名：瑞香素

英文别名：Spectrum4_001254|7,8-Dihydroxy-2H-1-benzopyran-2-one|XC84571RD2|KBio1_001904|ATEFPOUAMCWAQS-UHFFFAOYSA-N|BDBM50206006|BRD-K61269089-001-02-2|COUMARIN, 7,8-DIHYDROXY-|7,8-Dihydroxycoumarin, 90%|AE-641/02519040|NCGC00093770-02|NCGC00261015-01|Spectrum3_0007

规格或纯度：>90.0%(HPLC)

英文名称：Daphnetin

生化机理：Daphnetin is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma.It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.Protein kinase inhibitor (IC 50 values are 7.67, 9.33 and 25.01 μM for EGFR, PKA and PKC respectively). Inhibits EGFR competitively to ATP and non-competitively to the peptide substrate. Coumarin derivative.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

IUPAC Name：7,8-dihydroxychromen-2-one

INCHI：InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

InChi Key：ATEFPOUAMCWAQS-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C2=C1C=CC(=O)O2)O)O

Isomeric SMILES：C1=CC(=C(C2=C1C=CC(=O)O2)O)O

RTECS：GN6382600

PubChem CID：5280569

Reaxy-Rn：9372

溶解性：DMSO 150 mg/mL (842.03 mM; Need ultrasonic and warming)

熔点：256°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P264,P362+P364,P264+P265,P337+P317,P332+P317

Merck Index：2817

产品包装