产品名称

英文名称：Ivermectine

同义词

Ivermectin B1a、IVERMECTIN、Dihydroavermectin B1a、70288-86-7、22,23-Dihydroavermectin B1a、70161-11-4、71827-03-7、Ivermectin Component B1a、avermectin H2B1a、MK-933、5-O-demethyl-22,23-dihydroavermectin A1a、DTXSID8023181、CHEBI63941、91Y2202OUW、(2ae,4e,5's,6s,6'r,

产品性质

CAS编号：70288-86-7

分子式：C48H74O14

分子量：875.09

MDL号：MFCD00869511

PubChem编号：6321424

英文别名：Ivermectin B1a|IVERMECTIN|Dihydroavermectin B1a|70288-86-7|22,23-Dihydroavermectin B1a|70161-11-4|71827-03-7|Ivermectin Component B1a|avermectin H2B1a|MK-933|5-O-demethyl-22,23-dihydroavermectin A1a|DTXSID8023181|CHEBI63941|91Y2202OUW|(2ae,4e,5's,6s,6'r,

规格或纯度：分析标准品

英文名称：Ivermectine

生化机理：Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic avermectin medicine. Ivermectin is positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Ivermectin also modulates glutamate- and GABA-activated chloride channels. Ivermectin potentiates glycine-gated currents at low concentrations (30 nM).Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor. Allosteric effector of P2X 4 receptors. Antihelmintic. Modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 n

应用：Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：稳定，在水中溶解度极低。Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

IUPAC Name：(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

INCHI：InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChi Key：AZSNMRSAGSSBNP-XPNPUAGNSA-N

Canonical SMILES：CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C

Isomeric SMILES：CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C

WGK Germany：3

PubChem CID：6321424

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH312 Harmful in contact with skinH400 Very toxic to aquatic lifeH300 Fatal if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P330,P203,P301+P316,P318,P317,P319

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装