产品名称

英文名称：Tri(1-aziridinyl)phosphine sulfide

同义词

thiotepa、THIO-TEPA、52-24-4、Triethylenethiophosphoramide、Thioplex、Thiophosphamide、Tiofosfamid、Tiofosyl、Thiofozil、Tespamin、Girostan、Oncotepa、Tespamine、Tiofozil、Stepa、Tri(aziridin-1-yl)phosphine sulfide、Oncotiotepa、Thiotef、Tifosyl、Oncothio-tepa、TESPA、Tio-tef、塞替派、硫次膦基三氮丙啶、三胺硫磷、三亚乙基硫代磷酰胺、三(1-吖丙啶基)硫代磷酰、噻替派、N,N',N″-三乙撑硫代磷酰胺

产品性质

CAS编号：52-24-4

分子式：C6H12N3PS

分子量：189.22

EC号：200-135-7

MDL号：MFCD00145452

PubChem编号：5453

别名：塞替派|硫次膦基三氮丙啶|三胺硫磷|三亚乙基硫代磷酰胺|三(1-吖丙啶基)硫代磷酰|噻替派|N,N',N″-三乙撑硫代磷酰胺

英文别名：thiotepa|THIO-TEPA|52-24-4|Triethylenethiophosphoramide|Thioplex|Thiophosphamide|Tiofosfamid|Tiofosyl|Thiofozil|Tespamin|Girostan|Oncotepa|Tespamine|Tiofozil|Stepa|Tri(aziridin-1-yl)phosphine sulfide|Oncotiotepa|Thiotef|Tifosyl|Oncothio-tepa|TESPA|Tio-tef

规格或纯度：98%

英文名称：Tri(1-aziridinyl)phosphine sulfide

生化机理：该不稳定的氮碳基团会与 DNA 烷基化，从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离，从而阻止了细胞分裂。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).

ALogP：0.5

IUPAC Name：tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane

INCHI：InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChi Key：FOCVUCIESVLUNU-UHFFFAOYSA-N

Canonical SMILES：C1CN1P(=S)(N2CC2)N3CC3

Isomeric SMILES：C1CN1P(=S)(N2CC2)N3CC3

WGK Germany：3

RTECS：SZ2975000

PubChem CID：5453

UN Number：2811

Packing Group：I

ChEMBL Ligand：CHEMBL671

DrugBank Ligand：DB04572

CAS Registry No.：52-24-4

Wikipedia：ThioTEPA

PEP：thiotepa

DrugCentral Ligand：2638

溶解性：Soluble in benzene, acetone and methanol.

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowedH350 May cause cancer

预防措施声明：P301+P310,P264,P201,P308+P313

Class：6.1

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装