产品名称

英文名称：Tetraethylthiuram disulfide

同义词

TETD、Disulfiram、Contrapot、Ethyl tuads、Tetraethylthiuram disulfide、CHEBI4659、Ethyl Thiudad、Hoca、NSC 190940、Contralin、Tetraethylthiuram sulfide、Antiaethan、Disulfuram、Antabuse (TN)、Antalcol、diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate、Dupon 4472、双硫伦

产品性质

CAS编号：97-77-8

分子式：C10H20N2S4

分子量：296.54

Beilstein号：1712560

EC号：202-607-8

MDL号：MFCD00009048

PubChem编号：3117

别名：双硫伦

英文别名：TETD|Disulfiram|Contrapot|Ethyl tuads|Tetraethylthiuram disulfide|CHEBI4659|Ethyl Thiudad|Hoca|NSC 190940|Contralin|Tetraethylthiuram sulfide|Antiaethan|Disulfuram|Antabuse (TN)|Antalcol|diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate|Dupon 4472

规格或纯度：97%

英文名称：Tetraethylthiuram disulfide

应用：醇脱氢酶抑制剂。 An ALDH and tumor cell growth inhibitor

运输条件：常规运输

备注：250g卖完停产，不再备货

产品介绍：Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase醇脱氢酶抑制剂。 An ALDH and tumor cell growth inhibitorDisulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPaseAn ALDH and tumor cell growth inhibitor

ALogP：3.9

PubChem SID：488179744

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179744

IUPAC Name：diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate

INCHI：InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChi Key：AUZONCFQVSMFAP-UHFFFAOYSA-N

Canonical SMILES：CCN(CC)C(=S)SSC(=S)N(CC)CC

Isomeric SMILES：CCN(CC)C(=S)SSC(=S)N(CC)CC

WGK Germany：3

RTECS：JO1225000

PubChem CID：3117

Reaxy-Rn：1712560

DrugBank Ligand：DB00822

CAS Registry No.：97-77-8

ChEMBL Ligand：CHEMBL964

Wikipedia：Disulfiram

DrugCentral Ligand：928

溶解性：Soluble in water (4 mg/l at 25 °C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile

密度：1.27

熔点：69-71°C

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH317 May cause an allergic skin reactionH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P261,P273,P280,P302+P352,P321,P501,P264,P260,P270,P272,P333+P313,P362+P364,P391,P330,P301+P317,P319

Merck Index：3364

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装