克立咪唑 盐酸盐

产品分类

药靶配体

产品名称

中文名称：克立咪唑 盐酸盐

英文名称：Clemizole hydrochloride

同义词

Clemizole hydrochloride、1163-36-6、Clemizole HCl、Clemizole (hydrochloride)、Clemizole hydrochloride [JAN]、MLS000120342、DTXSID9045136、85W6I13D8M、NSC-759290、Allercur、SMR000058430、1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride、1-[(4-chl、1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐,盐酸克立咪唑、1-(4-氯苄基)-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐

产品性质

CAS编号：1163-36-6

分子式：C19H21Cl2N3

分子量：362.3

MDL号：MFCD00051435

PubChem编号：5309446

规格或纯度：98% (HPLC)

英文名称：Clemizole hydrochloride

生化机理：Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment. Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍Clemizole is a potent anti-allergic drug. Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂，抑制 HCV 复制。

IUPAC Name：1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;hydrochloride

INCHI：InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H

InChi Key：DNFMJYXRIMLMBZ-UHFFFAOYSA-N

Canonical SMILES：C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl

RTECS：DD6730000

PubChem CID：5309446

溶解性：H2O 2 mg/mL, clear (warmed)，≥15.13 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.12 mg/mL in DMSO; ≥5.12 mg/mL in H2O with gentle warming and ultrasonic

敏感性：对 热、空气敏感

熔点：241 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：2346

产品包装