产品名称

英文名称：M344

同义词

251456-60-7、m344、4-(dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamide、M 344、Histone Deacetylase Inhibitor III、4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide、N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide、M-344、Benzamide, 4-(dimet

产品性质

CAS编号：251456-60-7

分子式：C16H25N3O3

分子量：307.39

MDL号：MFCD03453554

PubChem编号：3994

英文别名：251456-60-7|m344|4-(dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamide|M 344|Histone Deacetylase Inhibitor III|4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide|N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide|M-344|Benzamide, 4-(dimet

规格或纯度：≥97%

英文名称：M344

生化机理：M344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.HDAC inhibitor (IC 50 = 100 nM). Shows selectivity for HDAC6. Inhibits growth of various cancer cells. Apoptosis inducer.

应用：A potent HDAC inhibitor with IC50 of 100.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：M344是一种有效的HDAC抑制剂，IC50为100 nM，可以诱导细胞分化。A potent HDAC inhibitor with IC50 of 100.M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.A potent HDAC inhibitor with IC50 of 100.

IUPAC Name：4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

INCHI：InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)

InChi Key：MXWDSZWTBOCWBK-UHFFFAOYSA-N

Canonical SMILES：CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

Isomeric SMILES：CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

WGK Germany：3

PubChem CID：3994

Reaxy-Rn：8570090

溶解性：Soluble in DMSO (62 mg/ml at 25 °C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).

敏感性：对热敏感

熔点：152 °C

产品包装