产品名称

英文名称：Baicalein

同义词

SpecPlus_000758、Spectrum5_001418、W-202870、baicalein、BAICALEIN [WHO-DD]、MFCD00017459、SDCCGMLS-0066744.P001、NCGC00025282-01、NCGC00025282-02、NCGC00025282-03、BAICALEIN [INCI]、Baicalein, 98%、HMS3412F14、HMS3655P18、MLS002473007、NCGC00017236-03、NSC661431、NSC-6614、三羟黄酮

产品性质

CAS编号：491-67-8

分子式：C15H10O5

分子量：270.24

Beilstein号：272683

MDL号：MFCD00017459

PubChem编号：5281605

别名：三羟黄酮

英文别名：SpecPlus_000758|Spectrum5_001418|W-202870|baicalein|BAICALEIN [WHO-DD]|MFCD00017459|SDCCGMLS-0066744.P001|NCGC00025282-01|NCGC00025282-02|NCGC00025282-03|BAICALEIN [INCI]|Baicalein, 98%|HMS3412F14|HMS3655P18|MLS002473007|NCGC00017236-03|NSC661431|NSC-6614

规格或纯度：分析标准品,≥98%

英文名称：Baicalein

生化机理：中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。

应用：An inhibitor of Ca2+ uptake, 5-LO, and 12-LO

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.An inhibitor of Ca2+ uptake, 5-LO, and 12-LOBaicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.An inhibitor of Ca2+ uptake, 5-LO, and 12-LO

IUPAC Name：5,6,7-trihydroxy-2-phenylchromen-4-one

INCHI：InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

InChi Key：FXNFHKRTJBSTCS-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O

Isomeric SMILES：C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O

WGK Germany：3

RTECS：DJ3100898

PubChem CID：5281605

Reaxy-Rn：272683

溶解性：Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water

密度：1.548

敏感性：对光和热敏感

熔点：256-271°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：942

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

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