产品名称

英文名称：CGK 733

同义词

CGK733、905973-89-9、CGK 733、CGK-733、2,2-Diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-nitrophenyl)thioureido)ethyl)acetamide、ATM/ATR Kinase Inhibitor、Diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea、2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-

产品性质

CAS编号：905973-89-9

分子式：C23H18Cl3FN4O3S

分子量：555.84

PubChem编号：6605258

英文别名：CGK733|905973-89-9|CGK 733|CGK-733|2,2-Diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-nitrophenyl)thioureido)ethyl)acetamide|ATM/ATR Kinase Inhibitor|Diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea|2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-

规格或纯度：≥99%

英文名称：CGK 733

生化机理：ATM/ATR Kinase Inhibitor (CGK733) Was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC50 ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product we retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated.Selective ATR and ATM kinase inhibitor. Shows antiproliferative effects in a range of cancer cell lines. Blocks recruitment and hyperphosphorylation of RPA2.

储存温度：2-8°C储存

运输条件：冰袋运输

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产品介绍：CGK 733是一种有效的ATM/ATR选择性抑制剂，IC50约为200 nM。A cell-permeable compound that inhibits kinase activity of ATM / ATR (RETRACTED).CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.A cell-permeable compound that inhibits kinase activity of ATM / ATR (RETRACTED).

IUPAC Name：2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide

INCHI：InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)

InChi Key：HLCDNLNLQNYZTK-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

Isomeric SMILES：C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

PubChem CID：6605258

溶解性：DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装