产品名称

英文名称：Lapatinib Ditosylate(GW-572016)

同义词

Lapatinib Ditosylate、388082-77-7、Tykerb、Tykerb Ditosylate、Lapatinib (ditosylate)、Lapatinib (GW-572016) Ditosylate、Tyverb、N-(3-CHLORO-4-((3-FLUOROBENZYL)OXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)FURAN-2-YL)QUINAZOLIN-4-AMINE BIS(4-METHYLBENZ

产品性质

CAS编号：388082-77-7

分子式：C29H26ClFN4O4S·2C7H8O3S

分子量：925.46

EC号：642-915-3,879-201-8

PubChem编号：9941095

英文别名：Lapatinib Ditosylate|388082-77-7|Tykerb|Tykerb Ditosylate|Lapatinib (ditosylate)|Lapatinib (GW-572016) Ditosylate|Tyverb|N-(3-CHLORO-4-((3-FLUOROBENZYL)OXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)FURAN-2-YL)QUINAZOLIN-4-AMINE BIS(4-METHYLBENZ

规格或纯度：≥98%

英文名称：Lapatinib Ditosylate(GW-572016)

生化机理：Lapatinib ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. ErbB-2 and EGFR dual tyrosine kinases are growth promoting factors that are over expressed in some breast cancer cell lines. Research studies have reported that Lapatinib Ditosylate can inhibit breast cancer cell proliferation.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：500mg、25mg、100mg卖完停产，不再备货

产品介绍：Lapatinib (GW-572016) Ditosylate是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.8和9.2 nM。Lapatinib Ditosylate (GW572016, GW2016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

IUPAC Name：N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid

INCHI：InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)

InChi Key：UWYXLGUQQFPJRI-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Isomeric SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

关联CAS：388082-78-8,388082-77-7

PubChem CID：9941095

MeSH Entry Terms：GW 282974X;GW 572016;GW-282974X;GW-572016;GW282974X;GW572016;lapatinib;lapatinib ditosylate;N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine;Tykerb

溶解性：DMSO 185 mg/mL Water Ethanol

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P263,P203,P318,P319

产品包装