产品名称

英文名称：Irinotecan

同义词

MFCD00866307 、 AB00698464-10 、 D08086 、 (+)-7-ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate 、 (+)-Irinotecan 、 CPT-11、伊立替康 、 依立替康 、 (S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3′,4′6,7]中氮茚并[1,2-b]喹啉-9-基酯 、 [1,4′-联吡啶]-1′-羧酸

产品性质

CAS编号：97682-44-5

分子式：C33H38N4O6

分子量：586.68

PubChem编号：60838

别名：伊立替康 | 依立替康 | (S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3′,4′6,7]中氮茚并[1,2-b]喹啉-9-基酯 | [1,4′-联吡啶]-1′-羧酸

英文别名：MFCD00866307 | AB00698464-10 | D08086 | (+)-7-ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate | (+)-Irinotecan | CPT-11

规格或纯度：≥99%

英文名称：Irinotecan

生化机理：(+)-Irinotecan is an isomer of the Topo I inhibitor Irinotecan

储存温度：2-8°C储存,避光

运输条件：冰袋运输

产品介绍：Irinotecan是一种Topoisomerase I抑制剂，作用于LoVo细胞和HT-29细胞，IC50分别为15.8 μM和5.17 μM。Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.Irinotecan hydrochloride has been usedin combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells.in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids.as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.

IUPAC Name：[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate

INCHI：InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1

InChi Key：UWKQSNNFCGGAFS-XIFFEERXSA-N

Canonical SMILES：CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

Isomeric SMILES：CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

PubChem CID：60838

DrugBank Ligand：DB00762

CAS Registry No.：97682-44-5

ChEMBL Ligand：CHEMBL481

Wikipedia：Irinotecan

RCSB PDB Ligand：CP0

PEP：irinotecan

DrugCentral Ligand：1482

溶解性：Soluble in DMSO (10 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

敏感性：对光线敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH318 Causes serious eye damageH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P330,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P332+P317,P319

产品包装