产品名称

英文名称：Istradefylline

同义词

Istradefylline、155270-99-8、KW-6002、nouriast、Nourianz、Istradefylline (KW-6002)、KW 6002、8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione、(E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione、KW6002、Istradef

产品性质

CAS编号：155270-99-8

分子式：C20H24N4O4

分子量：384.43

MDL号：MFCD00928421

PubChem编号：5311037

英文别名：Istradefylline|155270-99-8|KW-6002|nouriast|Nourianz|Istradefylline (KW-6002)|KW 6002|8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione|(E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione|KW6002|Istradef

规格或纯度：≥99%

英文名称：Istradefylline

生化机理：Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist in experimental models of Parkinson's disease. Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drμgs such as levodopa. Istradefylline is an analog of caffeine.Competitive inhibitor of adenosine A2A receptors. Selective for the adenosine A2A receptor (K i = 2.2 nM) versus the adenosine A1 receptor (K i = 150 nM). Increases dopamine levels in normal animals and Parkinson's disease anima

应用：A selective A(2A) antagonist used to study parkinson’s disease in vitro

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参考SDS，以获取更多信息。需要更多有关溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Istradefylline(KW6002)是口服活性的腺苷A2A受体拮抗剂，Ki为2.2 nM。A selective A(2A) antagonist used to study parkinson’s disease in vitroIstradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease.A selective A(2A) antagonist used to study parkinson’s disease in vitro

ALogP：2.5

IUPAC Name：8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione

INCHI：InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+

InChi Key：IQVRBWUUXZMOPW-PKNBQFBNSA-N

Canonical SMILES：CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C

Isomeric SMILES：CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C

WGK Germany：3

PubChem CID：5311037

ChEMBL Ligand：CHEMBL431770

CAS Registry No.：155270-99-8

Wikipedia：Istradefylline

DrugCentral Ligand：4882

GPCRdb Ligand：istradefylline

RCSB PDB Ligand：JQ9

溶解性：DMSO 6 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

熔点：193 °C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装