产品名称

英文名称：Podophyllotoxin

同义词

CCG-39894、KBioSS_000679、(-)-Podophyllotoxin、9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4'6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one、(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4'6,7]naphtho[2,3-d]-1、盾叶鬼臼

产品性质

CAS编号：518-28-5

分子式：C22H22O8

分子量：414.41

Beilstein号：99163

EC号：208-250-4

MDL号：MFCD00075290

PubChem编号：10607

别名：盾叶鬼臼

英文别名：CCG-39894|KBioSS_000679|(-)-Podophyllotoxin|9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4'6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one|(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4'6,7]naphtho[2,3-d]-1

规格或纯度：分析标准品,>98%

英文名称：Podophyllotoxin

生化机理：Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use.

应用：抑制微导管（microtubule）组装；抗肿瘤。 临床上用于急性单核细胞型和急性粒单核细胞型白血病，急性粒细胞白血病，慢性嗜酸粒细胞型白血病，小细胞肺癌，非何杰金氏恶性淋巴瘤、 睾丸癌等。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：无臭无味，不溶于水、 易溶于水、易溶于氯仿、 甲醇和丙酮。

ALogP：2

IUPAC Name：(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

INCHI：InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1

InChi Key：YJGVMLPVUAXIQN-XVVDYKMHSA-N

Canonical SMILES：COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O

Isomeric SMILES：COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O

WGK Germany：3

RTECS：LV2500000

PubChem CID：10607

UN Number：3462

比旋光度：-129° (C=1,CHCl3)

熔点：178-184°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH310 Fatal in contact with skin

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P262,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319

Merck Index：7546

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装