产品名称

英文名称：Paroxetine hydrochloride hemihydrate

同义词

Paroxetine hydrochloride hemihydrate、110429-35-1、Paxil、X2ELS050D8、Seroxat、Aropax、Paroxetine.HCl.hemihydrate、Paxil (TN)、(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-1-ium;chloride、(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluo、盐酸帕罗西汀半水合物

产品性质

CAS编号：110429-35-1

分子式：C19H20FNO3·HCl·1/2 H2O

分子量：374.83

MDL号：MFCD03658863

PubChem编号：5282487

别名：盐酸帕罗西汀半水合物

英文别名：Paroxetine hydrochloride hemihydrate|110429-35-1|Paxil|X2ELS050D8|Seroxat|Aropax|Paroxetine.HCl.hemihydrate|Paxil (TN)|(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-1-ium;chloride|(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluo

规格或纯度：≥98% (HPLC)

英文名称：Paroxetine hydrochloride hemihydrate

生化机理：Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant.Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (K i values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo .

应用：A highly potent and selective serotonin (5-HT) uptake inhibitor

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).A highly potent and selective serotonin (5-HT) uptake inhibitorParoxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).A highly potent and selective serotonin (5-HT) uptake inhibitor

ALogP：3.5

IUPAC Name：(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrate;dihydrochloride

INCHI：InChI=1S/2C19H20FNO3.2ClH.H2O/c2*20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;;/h2*1-6,9,14,17,21H,7-8,10-12H2;2*1H;1H2/t2*14-,17-;;;/m00.../s1

InChi Key：MQZOATSIFWSKKT-OASXIEIISA-N

Canonical SMILES：C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl

Isomeric SMILES：C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl

WGK Germany：3

RTECS：TM4569320

关联CAS：78246-49-8

PubChem CID：5282487

Reaxy-Rn：7471375

溶解性：Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insoluble in water

比旋光度：-90°C

熔点：137-139°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

Merck Index：7043

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装